7-Methoxy-2-phenyl-5-(piperidine-1-carbonyl)-5,8-dihydro-[1,2,4]triazolo[1,2-a]pyridazine-1,3-dione

Base Information

• Chemical Name: 7-Methoxy-2-phenyl-5-(piperidine-1-carbonyl)-5,8-dihydro-[1,2,4]triazolo[1,2-a]pyridazine-1,3-dione
• CAS No.: 178550-13-5
• Molecular Formula: C₁₉H₂₂N₄O₄
• Molecular Weight: 370.408

Synonyms:7-Methoxy-2-phenyl-5-(piperidine-1-carbonyl)-5,8-dihydro-[1,2,4]triazolo[1,2-a]pyridazine-1,3-dione

Chemical Property of 7-Methoxy-2-phenyl-5-(piperidine-1-carbonyl)-5,8-dihydro-[1,2,4]triazolo[1,2-a]pyridazine-1,3-dione

Chemical Property:

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Technology Process of 7-Methoxy-2-phenyl-5-(piperidine-1-carbonyl)-5,8-dihydro-[1,2,4]triazolo[1,2-a]pyridazine-1,3-dione

There total 2 articles about 7-Methoxy-2-phenyl-5-(piperidine-1-carbonyl)-5,8-dihydro-[1,2,4]triazolo[1,2-a]pyridazine-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-Phenyl-1,2,4-triazolidine-3,5-dione (4233-33-4) + (E)-4-Methoxy-1-piperidin-1-yl-penta-2,4-dien-1-one (178550-17-9) → 7-Methoxy-2-phenyl-5-(piperidine-1-carbonyl)-5,8-dihydro-[1,2,4]triazolo[1,2-a]pyridazine-1,3-dione (178550-13-5)

Guidance literature:

In tetrahydrofuran; at 50 ℃; for 48h; sealed tube;

DOI:10.1016/0040-4039(96)00631-4

Reference yield:

(2E,4E)-1-Piperidin-1-yl-5-(toluene-4-sulfonyl)-penta-2,4-dien-1-one (169701-77-3) → 7-Methoxy-2-phenyl-5-(piperidine-1-carbonyl)-5,8-dihydro-[1,2,4]triazolo[1,2-a]pyridazine-1,3-dione (178550-13-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / 1M KOH / 3 h / Ambient temperature

2: 80 percent / tetrahydrofuran / 48 h / 50 °C / sealed tube

With potassium hydroxide; In tetrahydrofuran;

DOI:10.1016/0040-4039(96)00631-4

Reference yield: 55.0%

7-Methoxy-2-phenyl-5-(piperidine-1-carbonyl)-5,8-dihydro-[1,2,4]triazolo[1,2-a]pyridazine-1,3-dione (178550-13-5) → 2-Phenyl-8-(piperidine-1-carbonyl)-dihydro-[1,2,4]triazolo[1,2-a]pyridazine-1,3,6-trione

Guidance literature:

With hydrogenchloride; In dichloromethane; water; for 24h;

DOI:10.1016/0040-4039(96)00631-4

upstream raw materials:

4-Phenyl-1,2,4-triazolidine-3,5-dione

(E)-4-Methoxy-1-piperidin-1-yl-penta-2,4-dien-1-one

(2E,4E)-1-Piperidin-1-yl-5-(toluene-4-sulfonyl)-penta-2,4-dien-1-one

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