tert-butyl (S)-2-((6R,7aS)-6-((tert-butyldiphenylsilyl)oxy)-2-oxo-6,7-dihydrobenzofuran-7a(2H)-yl)piperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl (S)-2-((6R,7aS)-6-((tert-butyldiphenylsilyl)oxy)-2-oxo-6,7-dihydrobenzofuran-7a(2H)-yl)piperidine-1-carboxylate
• CAS No.: 1067651-09-5
• Molecular Formula: C₃₄H₄₃NO₅Si
• Molecular Weight: 573.805
• Mol file: 1067651-09-5.mol

Synonyms:tert-butyl (S)-2-((6R,7aS)-6-((tert-butyldiphenylsilyl)oxy)-2-oxo-6,7-dihydrobenzofuran-7a(2H)-yl)piperidine-1-carboxylate

Chemical Property of tert-butyl (S)-2-((6R,7aS)-6-((tert-butyldiphenylsilyl)oxy)-2-oxo-6,7-dihydrobenzofuran-7a(2H)-yl)piperidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (S)-2-((6R,7aS)-6-((tert-butyldiphenylsilyl)oxy)-2-oxo-6,7-dihydrobenzofuran-7a(2H)-yl)piperidine-1-carboxylate

There total 2 articles about tert-butyl (S)-2-((6R,7aS)-6-((tert-butyldiphenylsilyl)oxy)-2-oxo-6,7-dihydrobenzofuran-7a(2H)-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

C33H46O3Si2 + tert-butyl 2-hydroxypiperidine-1-carboxylate (86953-81-3) → tert-butyl (S)-2-((6R,7aS)-6-((tert-butyldiphenylsilyl)oxy)-2-oxo-6,7-dihydrobenzofuran-7a(2H)-yl)piperidine-1-carboxylate (1067651-09-5) + (6R,7aR)-tert-butyl 2-(6-(tert-butyldiphenylsilanyloxy)-2-oxo-6,7-dihydro-2H-benzofuran-7a-yl)piperidine-1-carboxylate

Guidance literature:

With di-n-butylboryl trifluoromethanesulfonate; In diethyl ether; at -78 ℃; for 0.0833333h; Inert atmosphere;

DOI:10.1021/jo801470u

Reference yield: 69.0%

C33H46O3Si2 + tert-butyl 2-hydroxypiperidine-1-carboxylate (86953-81-3) → tert-butyl (S)-2-((6R,7aS)-6-((tert-butyldiphenylsilyl)oxy)-2-oxo-6,7-dihydrobenzofuran-7a(2H)-yl)piperidine-1-carboxylate (1067651-09-5) + tert-butyl-2-(6-((tert-butyldiphenylsilyl)oxy)-2-oxo-6,7-dihydrobenzofuran-7a(2H)-yl)piperidine-1-carboxylate

Guidance literature:

With di-n-butylboryl trifluoromethanesulfonate; In diethyl ether; at -78 ℃; for 0.166667h; stereoselective reaction;

DOI:10.1021/acs.orglett.6b03716

Reference yield: 97.0%

tert-butyl (S)-2-((6R,7aS)-6-((tert-butyldiphenylsilyl)oxy)-2-oxo-6,7-dihydrobenzofuran-7a(2H)-yl)piperidine-1-carboxylate (1067651-09-5) → (S)-2-((6R,7aS)-6-((tert-butyldiphenylsilyl)oxy)-2-oxo-6,7-dihydrobenzofuran-7a(2H)-yl)piperidin-1-ium chloride

Guidance literature:

With hydrogenchloride; In diethyl ether; at 45 ℃; for 10h; Microwave irradiation;

DOI:10.1021/acs.orglett.6b03716

upstream raw materials:

tert-butyl 2-hydroxypiperidine-1-carboxylate

Downstream raw materials:

Phyllochrysin