((3S,4S,5S,6S,7S)-8-(benzyloxy)-6-(4-methoxybenzyloxy)-3,5,7-trimethyl-1-((2R,3R)-3-methyloxetan-2-yl)octan-4-yloxy)(tert-butyl)dimethylsilane

Base Information

Chemical Name:((3S,4S,5S,6S,7S)-8-(benzyloxy)-6-(4-methoxybenzyloxy)-3,5,7-trimethyl-1-((2R,3R)-3-methyloxetan-2-yl)octan-4-yloxy)(tert-butyl)dimethylsilane
CAS No.:1616887-08-1
Molecular Formula:C₃₆H₅₈O₅Si
Molecular Weight:598.939
Hs Code.:

Synonyms:((3S,4S,5S,6S,7S)-8-(benzyloxy)-6-(4-methoxybenzyloxy)-3,5,7-trimethyl-1-((2R,3R)-3-methyloxetan-2-yl)octan-4-yloxy)(tert-butyl)dimethylsilane

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Chemical Property of ((3S,4S,5S,6S,7S)-8-(benzyloxy)-6-(4-methoxybenzyloxy)-3,5,7-trimethyl-1-((2R,3R)-3-methyloxetan-2-yl)octan-4-yloxy)(tert-butyl)dimethylsilane

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Technology Process of ((3S,4S,5S,6S,7S)-8-(benzyloxy)-6-(4-methoxybenzyloxy)-3,5,7-trimethyl-1-((2R,3R)-3-methyloxetan-2-yl)octan-4-yloxy)(tert-butyl)dimethylsilane

There total 12 articles about ((3S,4S,5S,6S,7S)-8-(benzyloxy)-6-(4-methoxybenzyloxy)-3,5,7-trimethyl-1-((2R,3R)-3-methyloxetan-2-yl)octan-4-yloxy)(tert-butyl)dimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1616887-18-3
(2R,3R,6S,7S,8S,9S,10S)-11-(benzyloxy)-7-(tert-butyldimethylsilyloxy)-3-hydroxy-9-(4-methoxybenzyloxy)-2,6,8,10-tetramethylundecyl 4-methylbenzenesulfonate

: 1616887-08-1
((3S,4S,5S,6S,7S)-8-(benzyloxy)-6-(4-methoxybenzyloxy)-3,5,7-trimethyl-1-((2R,3R)-3-methyloxetan-2-yl)octan-4-yloxy)(tert-butyl)dimethylsilane

Guidance literature:: With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.tetlet.2014.05.020

Reference yield:

: 1616887-17-2
(2R,3R,6S,7S,8S,9S,10S)-11-(benzyloxy)-7-(tert-butyldimethylsilyloxy)-9-(4-methoxybenzyloxy)-2,6,8,10-tetramethylundecane-1,3-diol

: 1616887-08-1
((3S,4S,5S,6S,7S)-8-(benzyloxy)-6-(4-methoxybenzyloxy)-3,5,7-trimethyl-1-((2R,3R)-3-methyloxetan-2-yl)octan-4-yloxy)(tert-butyl)dimethylsilane

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 0 °C / Inert atmosphere

2: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere

With pyridine; sodium hydride; In tetrahydrofuran; dichloromethane; mineral oil;
DOI:10.1016/j.tetlet.2014.05.020

Reference yield:

: C₁₈H₂₄O₅

: 1616887-08-1
((3S,4S,5S,6S,7S)-8-(benzyloxy)-6-(4-methoxybenzyloxy)-3,5,7-trimethyl-1-((2R,3R)-3-methyloxetan-2-yl)octan-4-yloxy)(tert-butyl)dimethylsilane

Guidance literature:: Multi-step reaction with 12 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / Inert atmosphere

2.1: pyridinium p-toluenesulfonate / dichloromethane / 20 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 - 20 °C / Inert atmosphere

3.2: 8 h / 0 - 20 °C / Inert atmosphere

4.1: pyridinium p-toluenesulfonate / methanol / 20 °C / Inert atmosphere

5.1: [bis(acetoxy)iodo]benzene; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane / 3 h / 0 °C / Inert atmosphere

5.2: 3 h / 20 °C / Inert atmosphere

6.1: triethylamine / dichloromethane / 0 °C / Inert atmosphere

7.1: nickel(II) chloride hexahydrate; sodium tetrahydroborate / methanol / 0 - 20 °C / Inert atmosphere

8.1: diisobutylaluminium hydride / dichloromethane; toluene / 0.5 h / -78 °C / Inert atmosphere

9.1: titanium tetrachloride / dichloromethane / 0.08 h / 0 °C / Inert atmosphere

9.2: 0.33 h / Inert atmosphere

9.3: 0.67 h / -78 °C / Inert atmosphere

10.1: sodium tetrahydroborate / methanol / 20 °C / Inert atmosphere

11.1: pyridine / dichloromethane / 0 °C / Inert atmosphere

12.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere

With pyridine; sodium tetrahydroborate; lithium aluminium tetrahydride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; nickel(II) chloride hexahydrate; [bis(acetoxy)iodo]benzene; pyridinium p-toluenesulfonate; titanium tetrachloride; sodium hydride; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; toluene; mineral oil; 9.3: |Evans Aldol Reaction;
DOI:10.1016/j.tetlet.2014.05.020