benzoic acid 10-{6-benzyloxy-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-9H-purin-2-ylamino}-7,8,9,10-tetrahydro-benzo[def]chrysen-9-yl ester

Base Information

Chemical Name:benzoic acid 10-{6-benzyloxy-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-9H-purin-2-ylamino}-7,8,9,10-tetrahydro-benzo[def]chrysen-9-yl ester
CAS No.:493039-76-2
Molecular Formula:C₅₆H₆₅N₅O₆Si₂
Molecular Weight:960.333
Hs Code.:

benzoic acid 10-{6-benzyloxy-9-[4-(<i>tert</i>-butyl-dimethyl-silanyloxy)-5-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-9<i>H</i>-purin-2-ylamino}-7,8,9,10-tetrahydro-benzo[<i>def</i>]chrysen-9-yl ester

Synonyms:benzoic acid 10-{6-benzyloxy-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-9H-purin-2-ylamino}-7,8,9,10-tetrahydro-benzo[def]chrysen-9-yl ester

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Chemical Property of benzoic acid 10-{6-benzyloxy-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-9H-purin-2-ylamino}-7,8,9,10-tetrahydro-benzo[def]chrysen-9-yl ester

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Technology Process of benzoic acid 10-{6-benzyloxy-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-9H-purin-2-ylamino}-7,8,9,10-tetrahydro-benzo[def]chrysen-9-yl ester

There total 2 articles about benzoic acid 10-{6-benzyloxy-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-9H-purin-2-ylamino}-7,8,9,10-tetrahydro-benzo[def]chrysen-9-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 128112-97-0,129552-36-9
(+/-)-trans-10-amino-9-(benzoyloxy)-7,8,9,10-tetrahydrobenzo pyrene

: 236427-58-0
2-bromo-6-benzyloxy-9-[2-deoxy-3,5-bis(O-tert-butyldimethylsilyl)-β-D-erythro-pentofuranosyl]purine

: 493039-76-2
benzoic acid 10-{6-benzyloxy-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-9H-purin-2-ylamino}-7,8,9,10-tetrahydro-benzo[def]chrysen-9-yl ester

Guidance literature:: With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 80 - 81 ℃; for 3.5h;
DOI:10.1021/ol027084w

Reference yield:

: 64608-56-6
9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene

: 493039-76-2
benzoic acid 10-{6-benzyloxy-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-9H-purin-2-ylamino}-7,8,9,10-tetrahydro-benzo[def]chrysen-9-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: LiN₃ / dimethylformamide / 24 h / 40 °C

1.2: Et₃N / dimethylformamide / 0.33 h / 20 °C

1.3: H₂ / Pd-C / tetrahydrofuran; methanol / 2.5 h / 20 °C / 760.05 Torr

2.1: 79 percent / palladium(II) acetate; (+/-)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl; Cs₂CO₃ / toluene / 3.5 h / 80 - 81 °C

With lithium azide; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In N,N-dimethyl-formamide; toluene;
DOI:10.1021/ol027084w

Reference yield:

: 493039-76-2
benzoic acid 10-{6-benzyloxy-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-9H-purin-2-ylamino}-7,8,9,10-tetrahydro-benzo[def]chrysen-9-yl ester

: trans-N²-[(10S)-(9-benzoyloxy-7,8,9,10-terahydro[a]pyrenyl)]-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine

: trans-N²-[(10R)-(9-benzoyloxy-7,8,9,10-terahydro[a]pyrenyl)]-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine

Guidance literature:: With palladium on activated charcoal; hydrogen; In tetrahydrofuran; methanol; at 20 ℃; for 5h; under 760.051 Torr;
DOI:10.1021/ol027084w