(R)-4-((S)-4-tert-Butoxycarbonylamino-pentanoylamino)-6-methyl-heptanoic acid benzyl ester

Base Information

Chemical Name:(R)-4-((S)-4-tert-Butoxycarbonylamino-pentanoylamino)-6-methyl-heptanoic acid benzyl ester
CAS No.:207924-97-8
Molecular Formula:C₂₅H₄₀N₂O₅
Molecular Weight:448.603
Hs Code.:

Synonyms:(R)-4-((S)-4-tert-Butoxycarbonylamino-pentanoylamino)-6-methyl-heptanoic acid benzyl ester

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Chemical Property of (R)-4-((S)-4-tert-Butoxycarbonylamino-pentanoylamino)-6-methyl-heptanoic acid benzyl ester

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Technology Process of (R)-4-((S)-4-tert-Butoxycarbonylamino-pentanoylamino)-6-methyl-heptanoic acid benzyl ester

There total 7 articles about (R)-4-((S)-4-tert-Butoxycarbonylamino-pentanoylamino)-6-methyl-heptanoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: (R)-4-Amino-6-methyl-heptanoic acid benzyl ester; compound with toluene-4-sulfonic acid

: 207924-92-3
(4S)-4-[(tert-butoxycarbonyl)amino]pentanoic acid

: 207924-97-8
(R)-4-((S)-4-tert-Butoxycarbonylamino-pentanoylamino)-6-methyl-heptanoic acid benzyl ester

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; 0 deg C, 1 h; r.t., 18 h;
DOI:10.1002/hlca.19980810514

Reference yield:

: (4S)-4-[(tert-butyloxycarbonyl)amino]-6-methylhept-2-enoic acid methyl ester

: 207924-97-8
(R)-4-((S)-4-tert-Butoxycarbonylamino-pentanoylamino)-6-methyl-heptanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / Pd/C / methanol / 20 h / 20 °C

2: NaOH / methanol / 20 h / 20 °C

3: 94 percent / benzene / 9 h / Heating

4: 95 percent / 1-hydroxy-1H-benzotriazole, N-methylmorpholine, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / tetrahydrofuran / 0 deg C, 1 h; r.t., 18 h

With 4-methyl-morpholine; sodium hydroxide; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In tetrahydrofuran; methanol; benzene;
DOI:10.1002/hlca.19980810514

Reference yield:

: (E)-(S)-4-tert-Butoxycarbonylamino-pent-2-enoic acid methyl ester

: 207924-97-8
(R)-4-((S)-4-tert-Butoxycarbonylamino-pentanoylamino)-6-methyl-heptanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd/C / methanol / 20 h / 20 °C

2: NaOH / methanol / 20 h / 20 °C

3: 95 percent / 1-hydroxy-1H-benzotriazole, N-methylmorpholine, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / tetrahydrofuran / 0 deg C, 1 h; r.t., 18 h

With 4-methyl-morpholine; sodium hydroxide; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1002/hlca.19980810514