methyl 1-{[(1,4-dichloro-7-isoquinolinyl)sulphonyl]amino}cyclohexanecarboxylate

Base Information

• Chemical Name: methyl 1-{[(1,4-dichloro-7-isoquinolinyl)sulphonyl]amino}cyclohexanecarboxylate
• CAS No.: 256477-68-6
• Molecular Formula: C₁₇H₁₈Cl₂N₂O₄S
• Molecular Weight: 417.313
• Mol file: 256477-68-6.mol

Synonyms:methyl 1-{[(1,4-dichloro-7-isoquinolinyl)sulphonyl]amino}cyclohexanecarboxylate

Chemical Property of methyl 1-{[(1,4-dichloro-7-isoquinolinyl)sulphonyl]amino}cyclohexanecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 1-{[(1,4-dichloro-7-isoquinolinyl)sulphonyl]amino}cyclohexanecarboxylate

There total 6 articles about methyl 1-{[(1,4-dichloro-7-isoquinolinyl)sulphonyl]amino}cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,4-dichloro-7-isoquinolinesulphonyl chloride (223671-80-5) + hexane-EtOAc + methyl 1-aminocyclohexanecarboxylate (4507-57-7) → methyl 1-{[(1,4-dichloro-7-isoquinolinyl)sulphonyl]amino}cyclohexanecarboxylate (256477-68-6)

Guidance literature:

With triethylamine; In dichloromethane;

Reference yield:

1,4-dichloro-7-isoquinolinesulphonyl chloride (223671-80-5) + methyl 1-aminocyclohexanecarboxylate (4507-57-7) → methyl 1-{[(1,4-dichloro-7-isoquinolinyl)sulphonyl]amino}cyclohexanecarboxylate (256477-68-6)

Guidance literature:

With triethylamine; In dichloromethane; at 23 ℃; for 16h;

DOI:10.1021/jm061066t

Reference yield:

1-isoquinolone (491-30-5) → methyl 1-{[(1,4-dichloro-7-isoquinolinyl)sulphonyl]amino}cyclohexanecarboxylate (256477-68-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 11.3 g / N-chlorosuccinimide / acetonitrile / 1.5 h / Heating

2: 18.75 g / ClSO₃H / 84 h / 100 °C

3: 20 g / POCl₃ / acetonitrile / 15 h / Heating

4: 132 mg / NEt₃ / CH₂Cl₂ / 16 h / 23 °C

With chlorosulfonic acid; N-chloro-succinimide; triethylamine; trichlorophosphate; In dichloromethane; acetonitrile;

DOI:10.1021/jm061066t

upstream raw materials:

1,4-dichloro-7-isoquinolinesulphonyl chloride

methyl 1-aminocyclohexanecarboxylate

4-chloro-1-oxo-1,2-dihydro-7-isoquinolinesulfonyl chloride

4-chloro-1-(2H)-isoquinolone

Downstream raw materials:

methyl 1-{[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]amino}cyclohexanecarboxylate