(S)-(4-((tert-butyldimethylsilyl)oxy)-1-oxobutan-2-yl)carbamic acid tert-butyl ester

Base Information

• Chemical Name: (S)-(4-((tert-butyldimethylsilyl)oxy)-1-oxobutan-2-yl)carbamic acid tert-butyl ester
• CAS No.: 1370043-50-7
• Molecular Formula: C₁₅H₃₁NO₄Si
• Molecular Weight: 317.501

Synonyms:(S)-(4-((tert-butyldimethylsilyl)oxy)-1-oxobutan-2-yl)carbamic acid tert-butyl ester

Chemical Property of (S)-(4-((tert-butyldimethylsilyl)oxy)-1-oxobutan-2-yl)carbamic acid tert-butyl ester

Chemical Property:

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Technology Process of (S)-(4-((tert-butyldimethylsilyl)oxy)-1-oxobutan-2-yl)carbamic acid tert-butyl ester

There total 1 articles about (S)-(4-((tert-butyldimethylsilyl)oxy)-1-oxobutan-2-yl)carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl (3S)-2-oxotetrahydrofuran-3-ylcarbamate (40856-59-5,132957-40-5) → (S)-(4-((tert-butyldimethylsilyl)oxy)-1-oxobutan-2-yl)carbamic acid tert-butyl ester (1370043-50-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dimethylaluminum chloride / hexanes; dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

1.2: 6 h / 0 °C / Inert atmosphere

2.1: 2,6-dimethylpyridine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 0 °C / Inert atmosphere

With 2,6-dimethylpyridine; lithium aluminium tetrahydride; dimethylaluminum chloride; In tetrahydrofuran; hexanes; dichloromethane;

DOI:10.1021/jo300205b

Reference yield: 75.0%

(S)-(4-((tert-butyldimethylsilyl)oxy)-1-oxobutan-2-yl)carbamic acid tert-butyl ester (1370043-50-7) + 4-(3,5-dimethylisoxazol-4-yl)-N1-((trans)-4-(methoxy-d3)cyclohexyl)benzene-1,2-diamine → C33H49(2)H3N4O5Si

Guidance literature:

With sodium metabisulfite; In N,N-dimethyl-formamide; at 80 ℃;

Reference yield: 70.6%

(S)-(4-((tert-butyldimethylsilyl)oxy)-1-oxobutan-2-yl)carbamic acid tert-butyl ester (1370043-50-7) + 4-(3,5-dimethylisoxazol-4-yl)-N1-((1r,4r)-4-methoxycyclohexyl)benzene-1,2-diamine → C33H52N4O5Si

Guidance literature:

With sodium metabisulfite; In N,N-dimethyl-formamide; at 80 ℃;

upstream raw materials:

tert-butyl (3S)-2-oxotetrahydrofuran-3-ylcarbamate

Downstream raw materials:

C₃₁H₄₅N₃O₅Si

benzyl (benzyl)((2S)-2-((tert-butoxycarbonyl)amino)-4-((tertbutyldimethylsilyl)oxy)-1-cyanobutyl)carbamate

benzyl (benzyl)((2S)-2-((tert-butoxycarbonyl)amino)-4-((tertbutyldimethylsilyl)oxy)-1-cyanobutyl)carbamate

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