(25ξ)-5α-bromo-26-<(tert-butyldiphenylsilyl)oxy>-6β,19-epoxy-5α-cholestan-3β-yl acetate

Base Information

Chemical Name:(25ξ)-5α-bromo-26-<(tert-butyldiphenylsilyl)oxy>-6β,19-epoxy-5α-cholestan-3β-yl acetate
CAS No.:137435-83-7
Molecular Formula:C₄₅H₆₅BrO₄Si
Molecular Weight:777.998
Hs Code.:

Synonyms:(25ξ)-5α-bromo-26-<(tert-butyldiphenylsilyl)oxy>-6β,19-epoxy-5α-cholestan-3β-yl acetate

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Chemical Property of (25ξ)-5α-bromo-26-<(tert-butyldiphenylsilyl)oxy>-6β,19-epoxy-5α-cholestan-3β-yl acetate

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Technology Process of (25ξ)-5α-bromo-26-<(tert-butyldiphenylsilyl)oxy>-6β,19-epoxy-5α-cholestan-3β-yl acetate

There total 7 articles about (25ξ)-5α-bromo-26-<(tert-butyldiphenylsilyl)oxy>-6β,19-epoxy-5α-cholestan-3β-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 137436-16-9
(25ξ)-5α-bromo-26-<(tert-butyldiphenylsilyl)oxy>-6β-hydroxy-5α-cholestan-3β-yl acetate

: 137435-83-7
(25ξ)-5α-bromo-26-<(tert-butyldiphenylsilyl)oxy>-6β,19-epoxy-5α-cholestan-3β-yl acetate

Guidance literature:: With lead(IV) acetate; iodine; calcium carbonate; In cyclohexane; for 3h; Heating; Irradiation;

Reference yield:

: 57984-04-0,71424-84-5,71424-85-6
6β-methoxy-3α,5-cyclo-5α-chol-23-en-22-ol

: 137435-83-7
(25ξ)-5α-bromo-26-<(tert-butyldiphenylsilyl)oxy>-6β,19-epoxy-5α-cholestan-3β-yl acetate

Guidance literature:: Multi-step reaction with 7 steps

1: 76 percent / propionic acid / xylene / 3 h / Heating

2: 100 percent / H₂ / PtO₂ / hexane / 30 h / 760 Torr

3: 6.7 g / LAH / diethyl ether / 0.5 h / Ambient temperature

4: 98 percent / imidazole / dimethylformamide / 1 h

5: 89 percent / 0.67 h / Heating

6: 50 percent / N-bromosuccinimide (NBS), aq. HClO₄ / 1.5 h / 0 - 20 °C

7: 75 percent / Pb(OAc)4, CaCO₃, I₂ / cyclohexane / 3 h / Heating; Irradiation

With 1H-imidazole; lead(IV) acetate; N-Bromosuccinimide; lithium aluminium tetrahydride; perchloric acid; hydrogen; iodine; propionic acid; calcium carbonate; platinum(IV) oxide; In diethyl ether; hexane; cyclohexane; N,N-dimethyl-formamide; xylene;

Reference yield:

: 137436-15-8
ethyl (25ξ,22E)-6β-methoxy-3α,5-cyclo-5α-cholest-22-en-26-oate

: 137435-83-7
(25ξ)-5α-bromo-26-<(tert-butyldiphenylsilyl)oxy>-6β,19-epoxy-5α-cholestan-3β-yl acetate

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / H₂ / PtO₂ / hexane / 30 h / 760 Torr

2: 6.7 g / LAH / diethyl ether / 0.5 h / Ambient temperature

3: 98 percent / imidazole / dimethylformamide / 1 h

4: 89 percent / 0.67 h / Heating

5: 50 percent / N-bromosuccinimide (NBS), aq. HClO₄ / 1.5 h / 0 - 20 °C

6: 75 percent / Pb(OAc)4, CaCO₃, I₂ / cyclohexane / 3 h / Heating; Irradiation

With 1H-imidazole; lead(IV) acetate; N-Bromosuccinimide; lithium aluminium tetrahydride; perchloric acid; hydrogen; iodine; calcium carbonate; platinum(IV) oxide; In diethyl ether; hexane; cyclohexane; N,N-dimethyl-formamide;