(4S,6S)-6-(2-Hydroxy)ethyl-1,4,5,5-tetramethylcyclohexene

Base Information

Chemical Name:(4S,6S)-6-(2-Hydroxy)ethyl-1,4,5,5-tetramethylcyclohexene
CAS No.:108032-54-8
Molecular Formula:C₁₂H₂₂O
Molecular Weight:182.306
Hs Code.:

Synonyms:(4S,6S)-6-(2-Hydroxy)ethyl-1,4,5,5-tetramethylcyclohexene

Suppliers and Price of (4S,6S)-6-(2-Hydroxy)ethyl-1,4,5,5-tetramethylcyclohexene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4S,6S)-6-(2-Hydroxy)ethyl-1,4,5,5-tetramethylcyclohexene

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4S,6S)-6-(2-Hydroxy)ethyl-1,4,5,5-tetramethylcyclohexene

There total 12 articles about (4S,6S)-6-(2-Hydroxy)ethyl-1,4,5,5-tetramethylcyclohexene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.7%

: 108032-53-7
(4S,6S)-6-(2-Benzyloxy)ethyl-1,4,5,5-tetramethylcyclohexene

: 108032-54-8
(4S,6S)-6-(2-Hydroxy)ethyl-1,4,5,5-tetramethylcyclohexene

Guidance literature:: With ammonia; sodium; In tetrahydrofuran; for 1h;
DOI:10.1248/cpb.39.2540

Reference yield:

: 138703-08-9
6-Benzyloxy-3-methyl-1,3-hexadiene

: 108032-54-8
(4S,6S)-6-(2-Hydroxy)ethyl-1,4,5,5-tetramethylcyclohexene

Guidance literature:: Multi-step reaction with 12 steps

1: 97.2 percent / hydroquinone / benzene / 19 h / Heating

2: 1) NaHCO₃, 2) KI, I₂ / 1) water, 2 h, r.t., 2) water, 17 h, r.t.

3: 4.58 g / BH₃*Me₂S, B(OMe)3 / tetrahydrofuran / 7 h / Ambient temperature

4: 63 percent / Zn-dust, AcOH / 1 h / 90 °C

5: 1) LDA / 1) THF, -65 deg C, 30 min, 2) -65 deg C, 4 h

6: 77.4 percent / i-Bu₂AlH / tetrahydrofuran; toluene / 1 h / -65 °C

7: CSA / benzene / 0.5 h

8: 91.6 percent / TsOH / dioxane; H₂O / 1 h / Heating

9: 90.3 percent / NaOH, 80percent N₂H₄ / bis-(2-hydroxy-ethyl) ether / 1) 35 min, 100 deg C, 2) to 210 deg C, 1 h, 3) 2 h, 210 deg C

10: 94.4 percent / Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

11: 94.4 percent / LiEt₃BH / tetrahydrofuran / 1 h / 50 °C

12: 96.7 percent / Na, liq. NH₃ / tetrahydrofuran / 1 h

With sodium hydroxide; Trimethyl borate; dimethylsulfide borane complex; camphor-10-sulfonic acid; ammonia; iodine; sodium; diisobutylaluminium hydride; lithium triethylborohydride; sodium hydrogencarbonate; toluene-4-sulfonic acid; hydrazine hydrate; acetic acid; triethylamine; hydroquinone; potassium iodide; zinc; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; toluene; diethylene glycol; benzene;
DOI:10.1248/cpb.39.2540

Reference yield:

: 107953-12-8,138808-87-4
(3aR*,7S*,7aS*)-7-(2-Benzyloxy)ethyl-6-methyl-3a,4,7,7a-tetrahydrophthalide

: 108032-54-8
(4S,6S)-6-(2-Hydroxy)ethyl-1,4,5,5-tetramethylcyclohexene

Guidance literature:: Multi-step reaction with 8 steps

1: 1) LDA / 1) THF, -65 deg C, 30 min, 2) -65 deg C, 4 h

2: 77.4 percent / i-Bu₂AlH / tetrahydrofuran; toluene / 1 h / -65 °C

3: CSA / benzene / 0.5 h

4: 91.6 percent / TsOH / dioxane; H₂O / 1 h / Heating

5: 90.3 percent / NaOH, 80percent N₂H₄ / bis-(2-hydroxy-ethyl) ether / 1) 35 min, 100 deg C, 2) to 210 deg C, 1 h, 3) 2 h, 210 deg C

6: 94.4 percent / Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

7: 94.4 percent / LiEt₃BH / tetrahydrofuran / 1 h / 50 °C

8: 96.7 percent / Na, liq. NH₃ / tetrahydrofuran / 1 h

With sodium hydroxide; camphor-10-sulfonic acid; ammonia; sodium; diisobutylaluminium hydride; lithium triethylborohydride; toluene-4-sulfonic acid; hydrazine hydrate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; toluene; diethylene glycol; benzene;
DOI:10.1248/cpb.39.2540