4-(4-bromo-3-(4-methoxyphenyl)-5-methyl-1H-pyrrol-2-yl)-3,5-dimethylisoxazole

Base Information

Chemical Name:4-(4-bromo-3-(4-methoxyphenyl)-5-methyl-1H-pyrrol-2-yl)-3,5-dimethylisoxazole
CAS No.:1289207-41-5
Molecular Formula:C₁₇H₁₇BrN₂O₂
Molecular Weight:361.238
Hs Code.:

Synonyms:4-(4-bromo-3-(4-methoxyphenyl)-5-methyl-1H-pyrrol-2-yl)-3,5-dimethylisoxazole

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Chemical Property of 4-(4-bromo-3-(4-methoxyphenyl)-5-methyl-1H-pyrrol-2-yl)-3,5-dimethylisoxazole

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Technology Process of 4-(4-bromo-3-(4-methoxyphenyl)-5-methyl-1H-pyrrol-2-yl)-3,5-dimethylisoxazole

There total 6 articles about 4-(4-bromo-3-(4-methoxyphenyl)-5-methyl-1H-pyrrol-2-yl)-3,5-dimethylisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1289207-40-4
4-(3-(4-methoxyphenyl)-5-methyl-1H-pyrrol-2-yl)-3,5-dimethylisoxazole

: 1289207-41-5
4-(4-bromo-3-(4-methoxyphenyl)-5-methyl-1H-pyrrol-2-yl)-3,5-dimethylisoxazole

Guidance literature:: With N-Bromosuccinimide; In tetrahydrofuran; at 0 ℃; for 0.333333h;

Reference yield:

: 2510-36-3
3,5-dimethyl-4-isoxazolecarboxylic acid

: 1289207-41-5
4-(4-bromo-3-(4-methoxyphenyl)-5-methyl-1H-pyrrol-2-yl)-3,5-dimethylisoxazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / 0.5 h / 80 °C

1.2: 20 °C

2.1: tetrahydrofuran / 0 - 20 °C

3.1: potassium carbonate / kryptofix 222 / 2 h / 85 °C

4.1: triethylamine; 3-ethyl-5-(2-hydroxyethyl)-4-methylthiazol-3-ium bromide triethylamine / ethanol / 0.5 h / 120 °C / Microwave irradiation

5.1: ammonium acetate / acetic acid / 0.5 h / 140 °C / Microwave irradiation

6.1: N-Bromosuccinimide / tetrahydrofuran / 0.33 h / 0 °C

With N-Bromosuccinimide; thionyl chloride; 3-ethyl-5-(2-hydroxyethyl)-4-methylthiazol-3-ium bromide triethylamine; ammonium acetate; potassium carbonate; triethylamine; kryptofix 222; In tetrahydrofuran; ethanol; acetic acid;

Reference yield:

: 1223452-45-6
N-methoxy-N-methyl-3,5-dimethylisoxazole-4-carboxamide

: 1289207-41-5
4-(4-bromo-3-(4-methoxyphenyl)-5-methyl-1H-pyrrol-2-yl)-3,5-dimethylisoxazole

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 0 - 20 °C

2: potassium carbonate / kryptofix 222 / 2 h / 85 °C

3: triethylamine; 3-ethyl-5-(2-hydroxyethyl)-4-methylthiazol-3-ium bromide triethylamine / ethanol / 0.5 h / 120 °C / Microwave irradiation

4: ammonium acetate / acetic acid / 0.5 h / 140 °C / Microwave irradiation

5: N-Bromosuccinimide / tetrahydrofuran / 0.33 h / 0 °C

With N-Bromosuccinimide; 3-ethyl-5-(2-hydroxyethyl)-4-methylthiazol-3-ium bromide triethylamine; ammonium acetate; potassium carbonate; triethylamine; kryptofix 222; In tetrahydrofuran; ethanol; acetic acid;