(2S,3S)-2-(tert-Butoxycarbonylmethyl-amino)-3-methyl-pentanoic acid benzyl ester; compound with toluene-4-sulfonic acid

Base Information

Chemical Name:(2S,3S)-2-(tert-Butoxycarbonylmethyl-amino)-3-methyl-pentanoic acid benzyl ester; compound with toluene-4-sulfonic acid
CAS No.:128708-23-6
Molecular Formula:C₇H₈O₃S*C₁₉H₂₉NO₄
Molecular Weight:507.648
Hs Code.:

Synonyms:(2S,3S)-2-(tert-Butoxycarbonylmethyl-amino)-3-methyl-pentanoic acid benzyl ester; compound with toluene-4-sulfonic acid

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Chemical Property of (2S,3S)-2-(tert-Butoxycarbonylmethyl-amino)-3-methyl-pentanoic acid benzyl ester; compound with toluene-4-sulfonic acid

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Technology Process of (2S,3S)-2-(tert-Butoxycarbonylmethyl-amino)-3-methyl-pentanoic acid benzyl ester; compound with toluene-4-sulfonic acid

There total 1 articles about (2S,3S)-2-(tert-Butoxycarbonylmethyl-amino)-3-methyl-pentanoic acid benzyl ester; compound with toluene-4-sulfonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 16652-75-8
L-isoleucine benzyl ester tosylate

: 128708-23-6
(2S,3S)-2-(tert-Butoxycarbonylmethyl-amino)-3-methyl-pentanoic acid benzyl ester; compound with toluene-4-sulfonic acid

Guidance literature:: With triethylamine; In tetrahydrofuran; for 144h; Ambient temperature;
DOI:10.1021/jm00171a034

Reference yield: 82.0%

: 128708-23-6
(2S,3S)-2-(tert-Butoxycarbonylmethyl-amino)-3-methyl-pentanoic acid benzyl ester; compound with toluene-4-sulfonic acid

: 128684-58-2
N-(carboxymethyl)-L-isoleucine benzyl ester hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; for 1h;
DOI:10.1021/jm00171a034

Reference yield:

: 128708-23-6
(2S,3S)-2-(tert-Butoxycarbonylmethyl-amino)-3-methyl-pentanoic acid benzyl ester; compound with toluene-4-sulfonic acid

: 128708-17-8
(3S,8R,11S)-8-Benzyl-3-((S)-sec-butyl)-2,6,9-trioxo-1,4,7,10-tetraaza-cyclopentadecane-11-carboxylic acid [(R)-2-(1H-indol-3-yl)-1-(3-methyl-butylcarbamoyl)-ethyl]-amide

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / 3N HCl / ethyl acetate / 1 h

2: 86 percent / dicyclohexylcarbodiimide (DCCI), 1-hydroxybenzotriazole (HOBt), triethylamine / dimethylformamide

3: 96 percent / H₂ / 10percent Pd-C / aq. ethanol

4: 9 percent / diphenyl phosphorazidate, NaHCO₃ / dimethylformamide / 4 °C

With hydrogenchloride; diphenyl phosphoryl azide; hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00171a034