4-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-N-phenylbenzamide

Base Information

Chemical Name:4-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-N-phenylbenzamide
CAS No.:1454656-28-0
Molecular Formula:C₂₀H₁₉N₅O
Molecular Weight:345.404
Hs Code.:

Synonyms:4-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-N-phenylbenzamide

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Chemical Property of 4-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-N-phenylbenzamide

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Technology Process of 4-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-N-phenylbenzamide

There total 8 articles about 4-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-N-phenylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1454657-39-6
4-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)benzoic acid

: 62-53-3
aniline

: 1454656-28-0
4-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-N-phenylbenzamide

Guidance literature:: 4-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)benzoic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 - 60 ℃; for 2h;

aniline; In N,N-dimethyl-formamide; at 20 - 60 ℃; for 22h;

Reference yield:

: 177-11-7
4,4-ethylenedioxy-piperidine

: 1454656-28-0
4-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-N-phenylbenzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: palladium diacetate; caesium carbonate; XPhos / tert-butyl alcohol; toluene / 18 h / 120 °C / Inert atmosphere; Sealed tube

2.1: sulfuric acid; water / tetrahydrofuran / 72 h / 20 °C

3.1: 1,4-dioxane / 40 h / Reflux

4.1: sodium acetate / ethanol / 16 h / Reflux

5.1: water; sodium hydroxide / 1,4-dioxane / 26 h / Reflux

6.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 20 - 60 °C

6.2: 22 h / 20 - 60 °C

With sulfuric acid; water; sodium acetate; palladium diacetate; caesium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; XPhos; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;

Reference yield:

: 1454657-36-3
methyl 4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)benzoate

: 1454656-28-0
4-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-N-phenylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid; water / tetrahydrofuran / 72 h / 20 °C

2.1: 1,4-dioxane / 40 h / Reflux

3.1: sodium acetate / ethanol / 16 h / Reflux

4.1: water; sodium hydroxide / 1,4-dioxane / 26 h / Reflux

5.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 20 - 60 °C

5.2: 22 h / 20 - 60 °C

With sulfuric acid; water; sodium acetate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide;