(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-((tert-butyldiphenylsilyl)oxy)propanoic acid

Base Information

Chemical Name:(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-((tert-butyldiphenylsilyl)oxy)propanoic acid
CAS No.:1359740-87-6
Molecular Formula:C₃₄H₃₅NO₅Si
Molecular Weight:565.741
Hs Code.:

Synonyms:(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-((tert-butyldiphenylsilyl)oxy)propanoic acid

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Chemical Property of (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-((tert-butyldiphenylsilyl)oxy)propanoic acid

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Technology Process of (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-((tert-butyldiphenylsilyl)oxy)propanoic acid

There total 3 articles about (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-((tert-butyldiphenylsilyl)oxy)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 73724-45-5
N-(9H-fluoren-9-ylmethoxycarbonyl)-L-serine

: 1359740-87-6
(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-((tert-butyldiphenylsilyl)oxy)propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / N,N-dimethyl-formamide / 6 h / 20 °C / Inert atmosphere

2: 1H-imidazole / tetrahydrofuran / 20 °C / Inert atmosphere

3: phenylsilane; palladium diacetate / dichloromethane / 3 h / 20 °C / Inert atmosphere

With 1H-imidazole; phenylsilane; palladium diacetate; caesium carbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol2034806

Reference yield:

: C₃₇H₃₉NO₅Si

: 1359740-87-6
(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-((tert-butyldiphenylsilyl)oxy)propanoic acid

Guidance literature:: With phenylsilane; palladium diacetate; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1021/ol2034806

Reference yield:

: 136497-85-3
N-(9-fluorenylmethoxycarbonyl)-L-serine allyl ester

: 1359740-87-6
(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-((tert-butyldiphenylsilyl)oxy)propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole / tetrahydrofuran / 20 °C / Inert atmosphere

2: phenylsilane; palladium diacetate / dichloromethane / 3 h / 20 °C / Inert atmosphere

With 1H-imidazole; phenylsilane; palladium diacetate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol2034806