KH₁₄₆-2

Base Information

• Chemical Name: KH₁₄₆-2
• CAS No.: 1391594-71-0
• Molecular Formula: C₅₆H₄₄F₆O₁₂S₂
• Molecular Weight: 1087.08
• Mol file: 1391594-71-0.mol

Synonyms:KH₁₄₆-2

Chemical Property of KH₁₄₆-2

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of KH₁₄₆-2

There total 3 articles about KH₁₄₆-2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

KH146-1 (1391594-70-9) → KH146-2 (1391594-71-0)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride; water / tetrahydrofuran; methanol / 24 h / 20 °C

2: pyridine / 24.5 h / 0 - 20 °C

With pyridine; hydrogenchloride; water; In tetrahydrofuran; methanol;

DOI:10.1039/c2cc31383a

Reference yield:

1-bromo-3-methoxy-5-(methoxymethoxy)benzene (1391594-69-6) → KH146-2 (1391594-71-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -80 °C / Inert atmosphere

1.2: 4 h / -80 - 20 °C / Inert atmosphere

1.3: 4 h / 80 °C / Inert atmosphere

2.1: hydrogenchloride; water / tetrahydrofuran; methanol / 24 h / 20 °C

3.1: pyridine / 24.5 h / 0 - 20 °C

With pyridine; hydrogenchloride; n-butyllithium; water; In tetrahydrofuran; methanol; hexane; 1.3: Suzuki-Miyaura coupling;

DOI:10.1039/c2cc31383a

Reference yield:

trifluoromethylsulfonic anhydride (358-23-6) + C54H46O8 → KH146-2 (1391594-71-0)

Guidance literature:

With pyridine; at 0 - 20 ℃; for 24.5h;

DOI:10.1039/c2cc31383a

upstream raw materials:

KH₁₄₆-1

1-bromo-3-methoxy-5-(methoxymethoxy)benzene

trifluoromethylsulfonic anhydride

Downstream raw materials:

KH-147