Benzyl 6-beta-Bromo-6-alpha-(ethoxyaminomethyl)penicillanate 1,1-Dioxide

Base Information

• Chemical Name: Benzyl 6-beta-Bromo-6-alpha-(ethoxyaminomethyl)penicillanate 1,1-Dioxide
• CAS No.: 93622-95-8
• Molecular Formula: C₁₈H₂₃BrN₂O₆S
• Molecular Weight: 475.36
• Mol file: 93622-95-8.mol

Synonyms:Benzyl 6-beta-Bromo-6-alpha-(ethoxyaminomethyl)penicillanate 1,1-Dioxide

Chemical Property of Benzyl 6-beta-Bromo-6-alpha-(ethoxyaminomethyl)penicillanate 1,1-Dioxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzyl 6-beta-Bromo-6-alpha-(ethoxyaminomethyl)penicillanate 1,1-Dioxide

There total 3 articles about Benzyl 6-beta-Bromo-6-alpha-(ethoxyaminomethyl)penicillanate 1,1-Dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

ethyl formaldoxime (93622-89-0) + C15H15Br2MgNO5S → (2S,5R,6S)-6-Bromo-6-(ethoxyamino-methyl)-3,3-dimethyl-4,4,7-trioxo-4λ6-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzyl ester (93622-95-8) + Benzyl 6-beta-Bromo-6-alpha-(ethoxyaminomethyl)penicillanate 1,1-Dioxide (93622-95-8)

Guidance literature:

With acetic acid; boron trifluoride diethyl etherate; In tetrahydrofuran; at -80 ℃;

DOI:10.1016/S0040-4039(00)84309-9

Reference yield: 5.0%

ethyl formaldoxime (93622-89-0) + C15H15Br2MgNO5S → (2S,5R,6S)-6-Bromo-6-(ethoxyamino-methyl)-3,3-dimethyl-4,4,7-trioxo-4λ6-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzyl ester (93622-95-8) + Benzyl 6-beta-Bromo-6-alpha-(ethoxyaminomethyl)penicillanate 1,1-Dioxide (93622-95-8)

Guidance literature:

With acetic acid; boron trifluoride diethyl etherate; In tetrahydrofuran; at -80 ℃;

DOI:10.1016/S0040-4039(00)84309-9

Reference yield:

BF3.etherate + CH3 CO2 H + CH3 MgCl + water (7732-18-5) + ethyl formaldoxime (93622-89-0) + benzyl (2S,5R)-6,6-dibromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo [3.2.0]-heptane-2-carboxylate-4,4-dioxide (76454-54-1) → Benzyl 6-beta-Bromo-6-alpha-(ethoxyaminomethyl)penicillanate 1,1-Dioxide (93622-95-8)

Guidance literature:

In tetrahydrofuran;

upstream raw materials:

ethyl formaldoxime

water

benzyl (2S,5R)-6,6-dibromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo [3.2.0]-heptane-2-carboxylate-4,4-dioxide

Downstream raw materials:

Benzyl 6-alpha-(Ethoxyaminomethyl)-penicillanate 1,1-Dioxide