2-methyl-4-(3-benzyloxy-4-methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)oxazole

Base Information

Chemical Name:2-methyl-4-(3-benzyloxy-4-methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)oxazole
CAS No.:424834-71-9
Molecular Formula:C₂₇H₂₇NO₆
Molecular Weight:461.514
Hs Code.:

Synonyms:2-methyl-4-(3-benzyloxy-4-methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)oxazole

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Chemical Property of 2-methyl-4-(3-benzyloxy-4-methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)oxazole

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Technology Process of 2-methyl-4-(3-benzyloxy-4-methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)oxazole

There total 5 articles about 2-methyl-4-(3-benzyloxy-4-methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 424834-70-8
acetic acid 2-(3-benzyloxy-4-methoxyphenyl)-2-oxo-1-(3,4,5-trimethoxyphenyl)ethyl ester

: 424834-71-9
2-methyl-4-(3-benzyloxy-4-methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)oxazole

Guidance literature:: With ammonium acetate; acetic acid; for 6h; Heating;
DOI:10.1021/jm010523x

Reference yield:

: 86-81-7
3,4,5-trimethoxy-benzaldehyde

: 424834-71-9
2-methyl-4-(3-benzyloxy-4-methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)oxazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: LDA / tetrahydrofuran / 0.33 h / -78 °C

1.2: tetrahydrofuran / 1 h / 20 °C

1.3: 10percent aq. HCl / tetrahydrofuran / 3 h

2.1: 99 percent / DMAP / CH₂Cl₂ / 4 h / 20 °C

3.1: 74 percent / NH₄OAc; AcOH / 6 h / Heating

With dmap; ammonium acetate; acetic acid; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm010523x

Reference yield:

: 6346-05-0
3-benzyloxy-4-methoxybenzaldehyde

: 424834-71-9
2-methyl-4-(3-benzyloxy-4-methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)oxazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: ZnI₂ / CH₂Cl₂ / 2 h / 20 °C

2.1: LDA / tetrahydrofuran / 0.33 h / -78 °C

2.2: tetrahydrofuran / 1 h / 20 °C

2.3: 10percent aq. HCl / tetrahydrofuran / 3 h

3.1: 99 percent / DMAP / CH₂Cl₂ / 4 h / 20 °C

4.1: 74 percent / NH₄OAc; AcOH / 6 h / Heating

With dmap; ammonium acetate; acetic acid; zinc(II) iodide; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm010523x