2-Pyrrolidinone, 1-(3-(4-(diphenylmethyl)-1-piperazinyl)propyl)-, dihydrochloride, hydrate

Base Information

Chemical Name:2-Pyrrolidinone, 1-(3-(4-(diphenylmethyl)-1-piperazinyl)propyl)-, dihydrochloride, hydrate
CAS No.:109758-21-6
Molecular Formula:C₂₄H₃₁N₃O*2ClH
Molecular Weight:450.452
Hs Code.:
DSSTox Substance ID:DTXSID00149029

Synonyms:M.G. 16220;2-Pyrrolidinone, 1-(3-(4-(diphenylmethyl)-1-piperazinyl)propyl)-, dihydrochloride, hydrate;1-(3-(4-(Diphenylmethyl)-1-piperazinyl)propyl)-2-pyrrolidinone dihydrochloride hydrate;109758-21-6;C24H31N3O.2ClH.H2O;DTXSID00149029;C24-H31-N3-O.2Cl-H.H2-O;LS-138757

Suppliers and Price of 2-Pyrrolidinone, 1-(3-(4-(diphenylmethyl)-1-piperazinyl)propyl)-, dihydrochloride, hydrate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Pyrrolidinone, 1-(3-(4-(diphenylmethyl)-1-piperazinyl)propyl)-, dihydrochloride, hydrate

Chemical Property:

Vapor Pressure:7.18E-12mmHg at 25°C
Boiling Point:543.4°Cat760mmHg
Flash Point:227.1°C
Density:g/cm³
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:7
Exact Mass:449.2000681
Heavy Atom Count:30
Complexity:458

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(=O)N(C1)CCCN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=CC=C4.Cl.Cl

Technology Process of 2-Pyrrolidinone, 1-(3-(4-(diphenylmethyl)-1-piperazinyl)propyl)-, dihydrochloride, hydrate

There total 2 articles about 2-Pyrrolidinone, 1-(3-(4-(diphenylmethyl)-1-piperazinyl)propyl)-, dihydrochloride, hydrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.3%

: 841-77-0
diphenylmethylpiperazine

: 91152-30-6
1-chloro-3-[2-oxo-pyrrolidin-1-yl]propane

: 109758-21-6
1-[3-(4-benzhydrylpiperazin-1-yl)propyl]pyrrolidin-2-one dihydrochloride

Guidance literature:: diphenylmethylpiperazine; 1-chloro-3-[2-oxo-pyrrolidin-1-yl]propane; at 150 ℃; for 6h; under 7500.75 Torr; Autoclave;

With hydrogenchloride; In ethanol;
DOI:10.1016/S1734-1140(10)70244-9

Reference yield:

: 62012-15-1
1-(3-hydroxypropyl)pyrrolidin-2-one

: 109758-21-6
1-[3-(4-benzhydrylpiperazin-1-yl)propyl]pyrrolidin-2-one dihydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / SOCl₂ / benzene / 3 h / Ambient temperature

2: 1.) KI, 2.) K₂CO₃ / 1.) isobutylmethylketone, reflux, 30 min, 2.) 48 h

With thionyl chloride; potassium carbonate; potassium iodide; In benzene;