2-[2-(5-bromo-2-fluoro-phenyl)-2-(2-nitro-benzenesulfonylamino)-propoxy]-3-fluoro-2-fluoromethyl-propionamide

Base Information

Chemical Name:2-[2-(5-bromo-2-fluoro-phenyl)-2-(2-nitro-benzenesulfonylamino)-propoxy]-3-fluoro-2-fluoromethyl-propionamide
CAS No.:1386985-80-3
Molecular Formula:C₁₉H₁₉BrF₃N₃O₆S
Molecular Weight:554.342
Hs Code.:

Synonyms:2-[2-(5-bromo-2-fluoro-phenyl)-2-(2-nitro-benzenesulfonylamino)-propoxy]-3-fluoro-2-fluoromethyl-propionamide

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Chemical Property of 2-[2-(5-bromo-2-fluoro-phenyl)-2-(2-nitro-benzenesulfonylamino)-propoxy]-3-fluoro-2-fluoromethyl-propionamide

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Technology Process of 2-[2-(5-bromo-2-fluoro-phenyl)-2-(2-nitro-benzenesulfonylamino)-propoxy]-3-fluoro-2-fluoromethyl-propionamide

There total 1 articles about 2-[2-(5-bromo-2-fluoro-phenyl)-2-(2-nitro-benzenesulfonylamino)-propoxy]-3-fluoro-2-fluoromethyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1386985-79-0
2-[2-(5-bromo-2-fluoro-phenyl)-2-(2-nitro-benzenesulfonylamino)-propoxy]-3-fluoro-2-fluoromethyl-propionic acid ethyl ester

: 1386985-80-3
2-[2-(5-bromo-2-fluoro-phenyl)-2-(2-nitro-benzenesulfonylamino)-propoxy]-3-fluoro-2-fluoromethyl-propionamide

Guidance literature:: With ammonia; In methanol; at 50 - 55 ℃; for 16h; Sealed tube;

Reference yield:

: 1386985-80-3
2-[2-(5-bromo-2-fluoro-phenyl)-2-(2-nitro-benzenesulfonylamino)-propoxy]-3-fluoro-2-fluoromethyl-propionamide

: 1386985-81-4
N-[1-(5-bromo-2-fluoro-phenyl)-2-(cyano-bis-fluoromethyl-methoxy)-1-methyl-ethyl]-2-nitro-benzenesulfonamide

Guidance literature:: With 4-methyl-morpholine; trifluoroacetic anhydride; In dichloromethane; at 20 ℃; for 0.75h;

Reference yield:

: 1386985-80-3
2-[2-(5-bromo-2-fluoro-phenyl)-2-(2-nitro-benzenesulfonylamino)-propoxy]-3-fluoro-2-fluoromethyl-propionamide

: 1386985-85-8
(5-{5-[(5-cyano-3-methyl-pyridine-2-carbonyl)-amino]-2-fluoro-phenyl}-2,2-bis-fluoromethyl-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: trifluoroacetic anhydride; 4-methyl-morpholine / dichloromethane / 0.75 h / 20 °C

2: potassium carbonate; N-Acetylcysteine / ethanol / 16 h / Reflux

3: dichloromethane / 16 h / 20 °C

4: sodium azide; copper(l) iodide; sodium L-ascorbate; trans-N,N'-dimethylcyclohexane-1,2-diamine / ethanol; water / 0.75 h / 70 °C / Inert atmosphere

5: hydrogen / 5%-palladium/activated carbon / ethanol / 1 h / 20 °C / 825.08 Torr

6: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / N,N-dimethyl-formamide / 3 h / 20 °C

With 4-methyl-morpholine; copper(l) iodide; sodium azide; 1-hydroxy-7-aza-benzotriazole; N-Acetylcysteine; hydrogen; potassium carbonate; trans-N,N'-dimethylcyclohexane-1,2-diamine; sodium L-ascorbate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic anhydride; 5%-palladium/activated carbon; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;