3-Fluoro-benzoic acid (2R,3aR,4R,6R,6aR)-2-(2-bromo-phenyl)-6-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl ester

Base Information

• Chemical Name: 3-Fluoro-benzoic acid (2R,3aR,4R,6R,6aR)-2-(2-bromo-phenyl)-6-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl ester
• CAS No.: 906640-38-8
• Molecular Formula: C₃₅H₃₄BrFO₆Si
• Molecular Weight: 677.639

Synonyms:3-Fluoro-benzoic acid (2R,3aR,4R,6R,6aR)-2-(2-bromo-phenyl)-6-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl ester

Chemical Property of 3-Fluoro-benzoic acid (2R,3aR,4R,6R,6aR)-2-(2-bromo-phenyl)-6-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl ester

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Technology Process of 3-Fluoro-benzoic acid (2R,3aR,4R,6R,6aR)-2-(2-bromo-phenyl)-6-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl ester

There total 1 articles about 3-Fluoro-benzoic acid (2R,3aR,4R,6R,6aR)-2-(2-bromo-phenyl)-6-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

(2R,3aR,6R,6aR)-2-(2-Bromo-phenyl)-6-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furo[3,4-d][1,3]dioxol-4-ol + 3-fluorobenzoic acid (455-38-9) → 3-Fluoro-benzoic acid (2R,3aR,4R,6R,6aR)-2-(2-bromo-phenyl)-6-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl ester (906640-38-8) + 3-Fluoro-benzoic acid (2R,3aR,4S,6R,6aR)-2-(2-bromo-phenyl)-6-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl ester

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/ol061162o

Reference yield: 89.0%

3-Fluoro-benzoic acid (2R,3aR,4R,6R,6aR)-2-(2-bromo-phenyl)-6-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl ester (906640-38-8) → 3-Fluoro-benzoic acid (2R,3aR,4R,6R,6aR)-2-(2-bromo-phenyl)-6-hydroxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl ester (906640-39-9)

Guidance literature:

With ammonium fluoride; In methanol; ethanol; at 20 ℃; for 48h;

DOI:10.1021/ol061162o

Reference yield: 35.0%

3-Fluoro-benzoic acid (2R,3aR,4R,6R,6aR)-2-(2-bromo-phenyl)-6-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl ester (906640-38-8) → 3-Fluoro-benzoic acid (2R,3aR,4R,6R,6aR)-6-(tert-butyl-diphenyl-silanyloxymethyl)-2-phenyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl ester + C35H34(2)HFO6Si + C35H34(2)HFO6Si + C35H34(2)HFO6Si

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tributyltin deuteride; In benzene; at 80 ℃; for 1h;

DOI:10.1021/ol061162o

upstream raw materials:

3-fluorobenzoic acid

Downstream raw materials:

3-Fluoro-benzoic acid (2R,3aR,4R,6R,6aR)-2-(2-bromo-phenyl)-6-hydroxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl ester

3-Fluoro-benzoic acid (2R,3aR,4R,6R,6aS)-6-(1-hydroxy-ethyl)-6-hydroxymethyl-2-phenyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl ester

3-Fluoro-benzoic acid (2R,3aR,4R,6R,6aR)-2-(2-bromo-phenyl)-6-(diphenyl-vinyl-silanyloxymethyl)-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl ester

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