4-bromo-N-[3-(chloromethyl)-8-ethyl-7-quinolinyl]benzamide hydrochloride

Base Information

Chemical Name:4-bromo-N-[3-(chloromethyl)-8-ethyl-7-quinolinyl]benzamide hydrochloride
CAS No.:521074-33-9
Molecular Formula:C₁₉H₁₆BrClN₂O*ClH
Molecular Weight:440.167
Hs Code.:

Synonyms:4-bromo-N-[3-(chloromethyl)-8-ethyl-7-quinolinyl]benzamide hydrochloride

Suppliers and Price of 4-bromo-N-[3-(chloromethyl)-8-ethyl-7-quinolinyl]benzamide hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-bromo-N-[3-(chloromethyl)-8-ethyl-7-quinolinyl]benzamide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-bromo-N-[3-(chloromethyl)-8-ethyl-7-quinolinyl]benzamide hydrochloride

There total 12 articles about 4-bromo-N-[3-(chloromethyl)-8-ethyl-7-quinolinyl]benzamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 521074-32-8
4-bromo-N-[8-ethyl-3-(hydroxymethyl)-7-quinolinyl]benzamide

: 521074-33-9
4-bromo-N-[3-(chloromethyl)-8-ethyl-7-quinolinyl]benzamide hydrochloride

Guidance literature:: With thionyl chloride; at 20 ℃; for 2h;
DOI:10.1021/jm201596h

Reference yield:

: C₁₉H₁₅BrN₂O₂

: 521074-33-9
4-bromo-N-[3-(chloromethyl)-8-ethyl-7-quinolinyl]benzamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / ethanol / 3 h / 20 °C / Cooling with ice

2: thionyl chloride / 2 h / 20 °C

With sodium tetrahydroborate; thionyl chloride; In ethanol;
DOI:10.1021/jm201596h

Reference yield:

: 521074-26-0
methyl 3-nitro-2-{[(trifluoromethyl)sulfonyl]oxy}benzoate

: 521074-33-9
4-bromo-N-[3-(chloromethyl)-8-ethyl-7-quinolinyl]benzamide hydrochloride

Guidance literature:: Multi-step reaction with 9 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 24 h / 80 °C / Inert atmosphere

2.1: hydrogenchloride / acetic acid / 4 h / 60 °C

3.1: diphenyl phosphoryl azide; triethylamine / 24 h / Reflux

4.1: 5%-palladium/activated carbon; hydrogen / ethanol / 5 h

5.1: triethylamine / tetrahydrofuran / 1 h / 0 - 20 °C

6.1: hydrogenchloride / tetrahydrofuran; ethyl acetate / 3 h / 60 °C

7.1: ethanol / 24 h / Reflux

7.2: 4 h / 20 °C

8.1: sodium tetrahydroborate / ethanol / 3 h / 20 °C / Cooling with ice

9.1: thionyl chloride / 2 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; diphenyl phosphoryl azide; 5%-palladium/activated carbon; hydrogen; triethylamine; In tetrahydrofuran; ethanol; acetic acid; ethyl acetate; N,N-dimethyl-formamide; 1.1: Stille coupling / 3.1: Curtius rearrangement;
DOI:10.1021/jm201596h