tert-butyl (R)-3-(4-amino-6-carbamoyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:tert-butyl (R)-3-(4-amino-6-carbamoyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyrrolidine-1-carboxylate
CAS No.:1610698-35-5
Molecular Formula:C₂₈H₃₀N₆O₄
Molecular Weight:514.584
Hs Code.:

Synonyms:tert-butyl (R)-3-(4-amino-6-carbamoyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyrrolidine-1-carboxylate

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Chemical Property of tert-butyl (R)-3-(4-amino-6-carbamoyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyrrolidine-1-carboxylate

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Technology Process of tert-butyl (R)-3-(4-amino-6-carbamoyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyrrolidine-1-carboxylate

There total 5 articles about tert-butyl (R)-3-(4-amino-6-carbamoyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1610698-24-2
tert-butyl (R)-3-(4-amino-6-cyano-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyrrolidine-1-carboxylate

: 1610698-35-5
tert-butyl (R)-3-(4-amino-6-carbamoyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyrrolidine-1-carboxylate

Guidance literature:: With water; sodium hydroxide; In 2-methoxy-ethanol; at 125 ℃; for 0.75h; Sealed tube; Microwave irradiation; Inert atmosphere;

Reference yield:

: 1610697-81-8
tert-butyl (R)-3-(4-amino-6-bromo-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyrrolidine-1-carboxylate

: 1610698-35-5
tert-butyl (R)-3-(4-amino-6-carbamoyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 100 °C / Inert atmosphere

2: sodium hydroxide; water / 2-methoxy-ethanol / 0.75 h / 125 °C / Sealed tube; Microwave irradiation; Inert atmosphere

With water; sodium hydroxide; In 2-methoxy-ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1272668-51-5
(R)-3-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyrrolidine-1-carboxylic acid tert-butyl ester

: 1610698-35-5
tert-butyl (R)-3-(4-amino-6-carbamoyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: ammonium hydroxide / 1,4-dioxane / 0.83 h / 120 °C / Microwave irradiation; Sealed tube

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / 1,2-dimethoxyethane; water / 90 °C / Inert atmosphere

3: N-Bromosuccinimide / dichloromethane / 0.5 h / 20 °C

4: N,N-dimethyl-formamide / 100 °C / Inert atmosphere

5: sodium hydroxide; water / 2-methoxy-ethanol / 0.75 h / 125 °C / Sealed tube; Microwave irradiation; Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; ammonium hydroxide; N-Bromosuccinimide; water; sodium carbonate; sodium hydroxide; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; 2-methoxy-ethanol; water; N,N-dimethyl-formamide;