5-(4-methylphenylsulfonyl)-5-azabicyclo[8.4.0]tetradeca-1⁽¹⁰⁾,11,13-triene-2,8-diyne

Base Information

• Chemical Name: 5-(4-methylphenylsulfonyl)-5-azabicyclo[8.4.0]tetradeca-1⁽¹⁰⁾,11,13-triene-2,8-diyne
• CAS No.: 259738-31-3
• Molecular Formula: C₂₀H₁₇NO₂S
• Molecular Weight: 335.426

Synonyms:5-(4-methylphenylsulfonyl)-5-azabicyclo[8.4.0]tetradeca-1⁽¹⁰⁾,11,13-triene-2,8-diyne

Chemical Property of 5-(4-methylphenylsulfonyl)-5-azabicyclo[8.4.0]tetradeca-1⁽¹⁰⁾,11,13-triene-2,8-diyne

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(4-methylphenylsulfonyl)-5-azabicyclo[8.4.0]tetradeca-1⁽¹⁰⁾,11,13-triene-2,8-diyne

There total 8 articles about 5-(4-methylphenylsulfonyl)-5-azabicyclo[8.4.0]tetradeca-1⁽¹⁰⁾,11,13-triene-2,8-diyne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-(1-methylsulfonyloxyprop-1-yn-1-yl)-1-[4-(4-methylphenylsulfonamido)but-1-yn-1-yl]benzene (259738-30-2) → 5-(4-methylphenylsulfonyl)-5-azabicyclo[8.4.0]tetradeca-1(10),11,13-triene-2,8-diyne (259738-31-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

DOI:10.1039/b000963f

Reference yield: 60.0%

2-(3-hydroxyprop-1-yn-1-yl)-1-[4-(4-methylphenylsulfonamido)but-1-yn-1-yl]benzene (259738-29-9) → 5-(4-methylphenylsulfonyl)-5-azabicyclo[8.4.0]tetradeca-1(10),11,13-triene-2,8-diyne (259738-31-3)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 0.5h;

DOI:10.1016/j.bmc.2008.02.044

Reference yield:

2-bromo-1-(1-hydroxy-3-butyn-4-yl)benzene (116510-00-0) → 5-(4-methylphenylsulfonyl)-5-azabicyclo[8.4.0]tetradeca-1(10),11,13-triene-2,8-diyne (259738-31-3)

Guidance literature:

Multi-step reaction with 7 steps

1: 85 percent / Et₃N / CH₂Cl₂ / 0.25 h / 20 °C

2: 78 percent / NaN₃ / dimethylformamide / 4 h / 20 °C

3: aq. PPh₃ / tetrahydrofuran / 20 h / 20 °C

4: 90 mg / Et₃N / CH₂Cl₂ / 3 h

5: 80 percent / n-BuNH₂ / Pd(PPh₃)4 / 20 h / Heating

6: 85 percent / Et₃N / CH₂Cl₂ / 0.25 h / 20 °C

7: 80 percent / K₂CO₃ / dimethylformamide / 3 h / 20 °C

With sodium azide; potassium carbonate; N-butylamine; triethylamine; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1: Substitution / 2: Substitution / 3: Reduction / 4: Tosylation / 5: Alkylation / 6: Substitution / 7: Cyclization;

DOI:10.1039/b000963f

upstream raw materials:

2-(1-methylsulfonyloxyprop-1-yn-1-yl)-1-[4-(4-methylphenylsulfonamido)but-1-yn-1-yl]benzene

2-bromo-1-(1-hydroxy-3-butyn-4-yl)benzene

4-(2-bromo-phenyl)-but-3-ynylamine

2-bromo-1-[4-azido(but-1-yn-1-yl)]benzene

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 259738-31-3 5-(4-methylphenylsulfonyl)-5-azabicyclo[8.4.0]tetradeca-1⁽¹⁰⁾,11,13-triene-2,8-diyne

Send

Send

Metric Ton KG G Pound L ML

Send

Send