N-(tert-butyloxycarbonyl)-D-(3-iodo-4-methoxyphenyl)glycine methyl ester

Base Information

Chemical Name:N-(tert-butyloxycarbonyl)-D-(3-iodo-4-methoxyphenyl)glycine methyl ester
CAS No.:218912-19-7
Molecular Formula:C₁₅H₂₀INO₅
Molecular Weight:421.232
Hs Code.:

Synonyms:N-(tert-butyloxycarbonyl)-D-(3-iodo-4-methoxyphenyl)glycine methyl ester

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Chemical Property of N-(tert-butyloxycarbonyl)-D-(3-iodo-4-methoxyphenyl)glycine methyl ester

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Technology Process of N-(tert-butyloxycarbonyl)-D-(3-iodo-4-methoxyphenyl)glycine methyl ester

There total 6 articles about N-(tert-butyloxycarbonyl)-D-(3-iodo-4-methoxyphenyl)glycine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 193073-85-7
methyl (R)-2-((tert-butoxycarbonyl)amino)-2-(4-methoxyphenyl)acetate

: 218912-19-7
N-(tert-butyloxycarbonyl)-D-(3-iodo-4-methoxyphenyl)glycine methyl ester

Guidance literature:: With iodine; silver trifluoroacetate; In chloroform; at 20 ℃; for 15h;
DOI:10.1039/c2ob25373a

Reference yield:

: 22818-40-2
D-4-hydroxyphenylglycine

: 218912-19-7
N-(tert-butyloxycarbonyl)-D-(3-iodo-4-methoxyphenyl)glycine methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: TMSCl / 15 h / 25 °C

2: K₂CO₃ / dioxane; H₂O / 4 h / 25 °C

3: 93 percent / K₂CO₃ / dimethylformamide / 6 h / 25 °C

4: 90 percent / I₂; CF₃COOAg / CHCl₃ / 12 h / 25 °C

With chloro-trimethyl-silane; iodine; silver trifluoroacetate; potassium carbonate; In 1,4-dioxane; chloroform; water; N,N-dimethyl-formamide; 1: Esterification / 2: Acylation / 3: Etherification / 4: Iodination;
DOI:10.1002/(SICI)1521-3765(19990903)5:9<2602::AID-CHEM2602>3.0.CO;2-X

Reference yield:

: 143323-49-3,141518-55-0
(R)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4-hydroxyphenyl)acetate

: 218912-19-7
N-(tert-butyloxycarbonyl)-D-(3-iodo-4-methoxyphenyl)glycine methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / K₂CO₃ / dimethylformamide / 6 h / 25 °C

2: 90 percent / I₂; CF₃COOAg / CHCl₃ / 12 h / 25 °C

With iodine; silver trifluoroacetate; potassium carbonate; In chloroform; N,N-dimethyl-formamide; 1: Etherification / 2: Iodination;
DOI:10.1002/(SICI)1521-3765(19990903)5:9<2602::AID-CHEM2602>3.0.CO;2-X