1-Boc-4-tert-butyl-5-(5-hydroxy-2-methylphenyl)-3,3-dimethyl-2,3-dihydropyrrole

Base Information

Chemical Name:1-Boc-4-tert-butyl-5-(5-hydroxy-2-methylphenyl)-3,3-dimethyl-2,3-dihydropyrrole
CAS No.:1309888-21-8
Molecular Formula:C₂₂H₃₃NO₃
Molecular Weight:359.509
Hs Code.:

Synonyms:1-Boc-4-tert-butyl-5-(5-hydroxy-2-methylphenyl)-3,3-dimethyl-2,3-dihydropyrrole

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Chemical Property of 1-Boc-4-tert-butyl-5-(5-hydroxy-2-methylphenyl)-3,3-dimethyl-2,3-dihydropyrrole

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Technology Process of 1-Boc-4-tert-butyl-5-(5-hydroxy-2-methylphenyl)-3,3-dimethyl-2,3-dihydropyrrole

There total 4 articles about 1-Boc-4-tert-butyl-5-(5-hydroxy-2-methylphenyl)-3,3-dimethyl-2,3-dihydropyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1309888-19-4
1-Boc-4-tert-butyl-5-(5-methoxy-2-methylphenyl)-3,3-dimethyl-2,3-dihydropyrrole

: 1309888-21-8
1-Boc-4-tert-butyl-5-(5-hydroxy-2-methylphenyl)-3,3-dimethyl-2,3-dihydropyrrole

Guidance literature:: With sodium thiomethoxide; In N,N-dimethyl-formamide; at 150 ℃; for 0.666667h; Inert atmosphere;
DOI:10.1021/jo2006945

Reference yield:

: 1309888-10-5
1-[N-Boc-N-(5-methoxy-2-methylbenzyl)]amino-2,2,4,4-tetramethylpentan-3-one

: 1309888-21-8
1-Boc-4-tert-butyl-5-(5-hydroxy-2-methylphenyl)-3,3-dimethyl-2,3-dihydropyrrole

Guidance literature:: Multi-step reaction with 3 steps

1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.3 h / 40 °C / Inert atmosphere

2: pyridine; thionyl chloride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

3: sodium thiomethoxide / N,N-dimethyl-formamide / 0.67 h / 150 °C / Inert atmosphere

With pyridine; n-butyllithium; thionyl chloride; diisopropylamine; sodium thiomethoxide; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1021/jo2006945

Reference yield:

: 90416-25-4
methoxy-5 methyl-2 α chloro toluene

: 1309888-21-8
1-Boc-4-tert-butyl-5-(5-hydroxy-2-methylphenyl)-3,3-dimethyl-2,3-dihydropyrrole

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C / Inert atmosphere

1.2: 16 h / 20 °C / Inert atmosphere

2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.3 h / 40 °C / Inert atmosphere

3.1: pyridine; thionyl chloride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

4.1: sodium thiomethoxide / N,N-dimethyl-formamide / 0.67 h / 150 °C / Inert atmosphere

With pyridine; n-butyllithium; thionyl chloride; sodium hydride; diisopropylamine; sodium thiomethoxide; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jo2006945