diethyl (4R)-[3-O-acetyl-2-O-benzoyl-1-(4-N-benzoylcytosin-1-yl)-1-deoxy-α-D-threofuranos-4-yl]phosphonate

Base Information

Chemical Name:diethyl (4R)-[3-O-acetyl-2-O-benzoyl-1-(4-N-benzoylcytosin-1-yl)-1-deoxy-α-D-threofuranos-4-yl]phosphonate
CAS No.:1333476-11-1
Molecular Formula:C₂₈H₃₀N₃O₁₀P
Molecular Weight:599.534
Hs Code.:

Synonyms:diethyl (4R)-[3-O-acetyl-2-O-benzoyl-1-(4-N-benzoylcytosin-1-yl)-1-deoxy-α-D-threofuranos-4-yl]phosphonate

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Chemical Property of diethyl (4R)-[3-O-acetyl-2-O-benzoyl-1-(4-N-benzoylcytosin-1-yl)-1-deoxy-α-D-threofuranos-4-yl]phosphonate

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Technology Process of diethyl (4R)-[3-O-acetyl-2-O-benzoyl-1-(4-N-benzoylcytosin-1-yl)-1-deoxy-α-D-threofuranos-4-yl]phosphonate

There total 8 articles about diethyl (4R)-[3-O-acetyl-2-O-benzoyl-1-(4-N-benzoylcytosin-1-yl)-1-deoxy-α-D-threofuranos-4-yl]phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1333476-08-6
diethyl (4R)-(1,3-di-O-acetyl-2-O-benzoyl-α-D-threofuranos-4-yl)phosphonate

: 238096-55-4
N-(2-((1-trimethylsilyl)oxy)pyrimidin-4-yl)benzamide

: 1333476-11-1
diethyl (4R)-[3-O-acetyl-2-O-benzoyl-1-(4-N-benzoylcytosin-1-yl)-1-deoxy-α-D-threofuranos-4-yl]phosphonate

Guidance literature:: With tin(IV) chloride; In acetonitrile; at -10 - 20 ℃; Inert atmosphere;
DOI:10.1135/cccc2011038

Reference yield:

: C₁₅H₂₁O₈P

: 1333476-11-1
diethyl (4R)-[3-O-acetyl-2-O-benzoyl-1-(4-N-benzoylcytosin-1-yl)-1-deoxy-α-D-threofuranos-4-yl]phosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: dmap / pyridine / 0.5 h

2: tin(IV) chloride / acetonitrile / -10 - 20 °C / Inert atmosphere

With dmap; tin(IV) chloride; In pyridine; acetonitrile;
DOI:10.1135/cccc2011038

Reference yield:

: diethyl (5R)-(3-O-benzoyl-1,2-O-isopropylidene-α-D-xylofuranos-5-C-yl)phosphonate

: 1333476-11-1
diethyl (4R)-[3-O-acetyl-2-O-benzoyl-1-(4-N-benzoylcytosin-1-yl)-1-deoxy-α-D-threofuranos-4-yl]phosphonate

Guidance literature:: Multi-step reaction with 3 steps

1: periodic acid dihydrate / 1,4-dioxane; water / 48 h / 50 °C / Darkness

2: dmap / pyridine / 0.5 h

3: tin(IV) chloride / acetonitrile / -10 - 20 °C / Inert atmosphere

With dmap; periodic acid dihydrate; tin(IV) chloride; In 1,4-dioxane; pyridine; water; acetonitrile;
DOI:10.1135/cccc2011038