methyl 2-[(triphenylphosphoranylidene)amino]thiophene-3-carboxylate

Base Information

• Chemical Name: methyl 2-[(triphenylphosphoranylidene)amino]thiophene-3-carboxylate
• CAS No.: 1353680-71-3
• Molecular Formula: C₂₄H₂₀NO₂PS
• Molecular Weight: 417.468
• Mol file: 1353680-71-3.mol

Synonyms:methyl 2-[(triphenylphosphoranylidene)amino]thiophene-3-carboxylate

Chemical Property of methyl 2-[(triphenylphosphoranylidene)amino]thiophene-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-[(triphenylphosphoranylidene)amino]thiophene-3-carboxylate

There total 1 articles about methyl 2-[(triphenylphosphoranylidene)amino]thiophene-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

Methyl 2-aminothiophene-3-carboxylate (4651-81-4) + triphenylphosphine (603-35-0) → methyl 2-[(triphenylphosphoranylidene)amino]thiophene-3-carboxylate (1353680-71-3)

Guidance literature:

With hexachloroethane; triethylamine; In toluene; at 20 ℃; for 6h;

DOI:10.1055/s-0030-1260217

Reference yield:

methyl 2-[(triphenylphosphoranylidene)amino]thiophene-3-carboxylate (1353680-71-3) → 3-phenyl-2-(phenylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one (1353680-79-1)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 1 h / 20 °C

2: potassium carbonate / tetrahydrofuran / Reflux

With potassium carbonate; In tetrahydrofuran; 1: Wittig type reaction;

DOI:10.1055/s-0030-1260217

Reference yield:

methyl 2-[(triphenylphosphoranylidene)amino]thiophene-3-carboxylate (1353680-71-3) → C27H22N6O2S2 (1353680-99-5)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 1 h / 20 °C

2: potassium carbonate / tetrahydrofuran / 12 h / Reflux

With potassium carbonate; In tetrahydrofuran; 1: Wittig type reaction;

DOI:10.1055/s-0030-1260217

upstream raw materials:

Methyl 2-aminothiophene-3-carboxylate

triphenylphosphine

Downstream raw materials:

3-phenyl-2-(phenylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one

C₂₇H₂₂N₆O₂S₂

2,2'-[1,4-phenylenedi(sulfanediyl)]bis(3-phenylthieno[2,3-d]pyrimidin-4(3H)-one)

2-(isobutylamino)-3-phenylthieno[2,3-d]pyrimidin-4(3H)-one