benzyl 2-((3-(4-methoxyphenyl)isoxazol-5-yl)methylamino)-2-oxoethylcarbamate

Base Information

• Chemical Name: benzyl 2-((3-(4-methoxyphenyl)isoxazol-5-yl)methylamino)-2-oxoethylcarbamate
• CAS No.: 1262439-67-7
• Molecular Formula: C₂₁H₂₁N₃O₅
• Molecular Weight: 395.415
• Mol file: 1262439-67-7.mol

Synonyms:benzyl 2-((3-(4-methoxyphenyl)isoxazol-5-yl)methylamino)-2-oxoethylcarbamate

Chemical Property of benzyl 2-((3-(4-methoxyphenyl)isoxazol-5-yl)methylamino)-2-oxoethylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl 2-((3-(4-methoxyphenyl)isoxazol-5-yl)methylamino)-2-oxoethylcarbamate

There total 7 articles about benzyl 2-((3-(4-methoxyphenyl)isoxazol-5-yl)methylamino)-2-oxoethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(3-(4-methoxyphenyl)isoxazol-5-yl)methaneamine (338982-43-7) + C15H19NO6 (41445-61-8) → benzyl 2-((3-(4-methoxyphenyl)isoxazol-5-yl)methylamino)-2-oxoethylcarbamate (1262439-67-7)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/jm1008715

Reference yield:

p-methoxyl benzaldoxime (3717-21-3,3717-22-4,140461-28-5,140461-29-6,3235-04-9) → benzyl 2-((3-(4-methoxyphenyl)isoxazol-5-yl)methylamino)-2-oxoethylcarbamate (1262439-67-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: chloroamine-T / water; tert-butyl alcohol / 20 °C

1.2: 20 °C

2.1: triethylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere

3.1: sodium azide / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

4.1: triphenylphosphine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

5.1: triethylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere

With sodium azide; chloroamine-T; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; 1.2: Huisgen cycloaddition / 4.1: Staudinger reaction / 4.2: Staudinger reaction;

DOI:10.1021/jm1008715

Reference yield:

5-(azidomethyl)-3-(4-methoxyphenyl)isoxazole (1262439-59-7) → benzyl 2-((3-(4-methoxyphenyl)isoxazol-5-yl)methylamino)-2-oxoethylcarbamate (1262439-67-7)

Guidance literature:

Multi-step reaction with 2 steps

1: triphenylphosphine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere

With triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; 1: Staudinger reaction / 1: Staudinger reaction;

DOI:10.1021/jm1008715

upstream raw materials:

p-methoxyl benzaldoxime

(3-(4-methoxyphenyl)isoxazol-5-yl)methyl 4-methylbenzenesulfonate

5-(azidomethyl)-3-(4-methoxyphenyl)isoxazole

1-(3-(4-methoxyphenyl)isoxazol-5-yl)methaneamine

Downstream raw materials:

3-(4-methoxy-phenyl)-5-methylisoxazole