(1R,2S,3R,5R,6R)-2-amino-2-cyano-3-[(3,4-dichloro benzyl)oxy]-6-fluoro bicyclo[3.1.0]hexane-6-carboxylic acid

Base Information

Chemical Name:(1R,2S,3R,5R,6R)-2-amino-2-cyano-3-[(3,4-dichloro benzyl)oxy]-6-fluoro bicyclo[3.1.0]hexane-6-carboxylic acid
CAS No.:1308835-67-7
Molecular Formula:C₁₅H₁₃Cl₂FN₂O₃
Molecular Weight:359.184
Hs Code.:

Synonyms:(1R,2S,3R,5R,6R)-2-amino-2-cyano-3-[(3,4-dichloro benzyl)oxy]-6-fluoro bicyclo[3.1.0]hexane-6-carboxylic acid

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Chemical Property of (1R,2S,3R,5R,6R)-2-amino-2-cyano-3-[(3,4-dichloro benzyl)oxy]-6-fluoro bicyclo[3.1.0]hexane-6-carboxylic acid

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Technology Process of (1R,2S,3R,5R,6R)-2-amino-2-cyano-3-[(3,4-dichloro benzyl)oxy]-6-fluoro bicyclo[3.1.0]hexane-6-carboxylic acid

There total 6 articles about (1R,2S,3R,5R,6R)-2-amino-2-cyano-3-[(3,4-dichloro benzyl)oxy]-6-fluoro bicyclo[3.1.0]hexane-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1308835-53-1
(1R,2S,3R,5R,6R)-2-amino-2-cyano-3-[(3,4-dichloro benzyl)oxy]-6-fluoro bicyclo[3.1.0]hexane-6-carboxamide

: 1308835-67-7
(1R,2S,3R,5R,6R)-2-amino-2-cyano-3-[(3,4-dichloro benzyl)oxy]-6-fluoro bicyclo[3.1.0]hexane-6-carboxylic acid

Guidance literature:: With hydrogenchloride; water; In acetic acid; at 75 ℃; for 6h;

Reference yield:

: 260353-79-5
ethyl (-)-(1R,5R,6R)-6-fluoro-2-oxobicyclo[3.1.0]hexane-6-carboxylate

: 1308835-67-7
(1R,2S,3R,5R,6R)-2-amino-2-cyano-3-[(3,4-dichloro benzyl)oxy]-6-fluoro bicyclo[3.1.0]hexane-6-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / toluene / 5 °C

2.1: dihydrogen peroxide / toluene / 1.33 h / 30 - 45 °C

3.1: trifluorormethanesulfonic acid / TETRAHYDROPYRANE / 1.75 h / 24 - 31 °C

4.1: ammonia / methanol / 1.15 h / 17 - 25 °C / Inert atmosphere

4.2: 4.63 h / 0 - 25 °C

4.3: 20.58 h / -6 - 0 °C

5.1: hydrogenchloride; water / acetic acid / 6 h / 75 °C

With hydrogenchloride; trifluorormethanesulfonic acid; ammonia; water; dihydrogen peroxide; triethylamine; In TETRAHYDROPYRANE; methanol; acetic acid; toluene;

Reference yield:

: 748780-77-0
3,4-dichlorobenzyl-2,2,2-trichloroacetoimidate

: 1308835-67-7
(1R,2S,3R,5R,6R)-2-amino-2-cyano-3-[(3,4-dichloro benzyl)oxy]-6-fluoro bicyclo[3.1.0]hexane-6-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluorormethanesulfonic acid / TETRAHYDROPYRANE / 1.75 h / 24 - 31 °C

2.1: ammonia / methanol / 1.15 h / 17 - 25 °C / Inert atmosphere

2.2: 4.63 h / 0 - 25 °C

2.3: 20.58 h / -6 - 0 °C

3.1: hydrogenchloride; water / acetic acid / 6 h / 75 °C

With hydrogenchloride; trifluorormethanesulfonic acid; ammonia; water; In TETRAHYDROPYRANE; methanol; acetic acid;