N-((6-trifluoromethyl-2-(4-(trifluoromethyl)cyclohexyloxy)pyridin-3-yl)methyl)-2-(3-fluoro-4-(methylsulfonamido)phenyl)propanamide

Base Information

Chemical Name:N-((6-trifluoromethyl-2-(4-(trifluoromethyl)cyclohexyloxy)pyridin-3-yl)methyl)-2-(3-fluoro-4-(methylsulfonamido)phenyl)propanamide
CAS No.:935516-71-5
Molecular Formula:C₂₄H₂₆F₇N₃O₄S
Molecular Weight:585.543
Hs Code.:

Synonyms:N-((6-trifluoromethyl-2-(4-(trifluoromethyl)cyclohexyloxy)pyridin-3-yl)methyl)-2-(3-fluoro-4-(methylsulfonamido)phenyl)propanamide

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Chemical Property of N-((6-trifluoromethyl-2-(4-(trifluoromethyl)cyclohexyloxy)pyridin-3-yl)methyl)-2-(3-fluoro-4-(methylsulfonamido)phenyl)propanamide

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Technology Process of N-((6-trifluoromethyl-2-(4-(trifluoromethyl)cyclohexyloxy)pyridin-3-yl)methyl)-2-(3-fluoro-4-(methylsulfonamido)phenyl)propanamide

There total 4 articles about N-((6-trifluoromethyl-2-(4-(trifluoromethyl)cyclohexyloxy)pyridin-3-yl)methyl)-2-(3-fluoro-4-(methylsulfonamido)phenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 824426-35-9
2-[3-fluoro-4-(methylsulfonylamino)phenyl]propionic acid

: 935519-95-2
C-[6-trifluoromethyl-2-(4-trifluoromethyl-cyclohexyloxy)-pyridin-3-yl]-methylamine

: 935516-71-5
N-((6-trifluoromethyl-2-(4-(trifluoromethyl)cyclohexyloxy)pyridin-3-yl)methyl)-2-(3-fluoro-4-(methylsulfonamido)phenyl)propanamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In water; N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1016/j.ejmech.2013.04.003

Reference yield:

: 116548-04-0
2-hydroxy-6-(trifluoromethyl)nicotinonitrile

: 935516-71-5
N-((6-trifluoromethyl-2-(4-(trifluoromethyl)cyclohexyloxy)pyridin-3-yl)methyl)-2-(3-fluoro-4-(methylsulfonamido)phenyl)propanamide

Guidance literature:: Multi-step reaction with 3 steps

1: 18-crown-6 ether; potassium carbonate / N,N-dimethyl-formamide / 60 - 90 °C

2: dimethylsulfide borane complex / tetrahydrofuran / 8 h / Reflux

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide; water / 12 h / 20 °C

With 18-crown-6 ether; dimethylsulfide borane complex; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2013.04.003

Reference yield:

: 30129-20-5
Trifluormethylcyclohexylbromid

: 935516-71-5
N-((6-trifluoromethyl-2-(4-(trifluoromethyl)cyclohexyloxy)pyridin-3-yl)methyl)-2-(3-fluoro-4-(methylsulfonamido)phenyl)propanamide

Guidance literature:: Multi-step reaction with 3 steps

1: 18-crown-6 ether; potassium carbonate / N,N-dimethyl-formamide / 60 - 90 °C

2: dimethylsulfide borane complex / tetrahydrofuran / 8 h / Reflux

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide; water / 12 h / 20 °C

With 18-crown-6 ether; dimethylsulfide borane complex; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2013.04.003