RESISTOMYCIN

Base Information

• Chemical Name: RESISTOMYCIN
• CAS No.: 20004-62-0
• Molecular Formula: C₂₂H₁₆O₆
• Molecular Weight: 376.365
• Hs Code.: 2914400090
• Mol file: 20004-62-0.mol

Synonyms:2H-Benzo[cd]pyrene-2,6(1H)-dione,3,5,7,10-tetrahydroxy-1,1,9-trimethyl- (8CI,9CI); Resistomycin (6CI);Antibiotic A 3733A; Geliomycin; Itamycin; X 340

Chemical Property of RESISTOMYCIN

Chemical Property:

• Melting Point: 325℃ (decomposition)
• Refractive Index: 1.4450 (estimate)
• Boiling Point: 424.93°C (rough estimate)
• PKA: 4.25±0.40(Predicted)
• PSA: 115.06000
• Density: 1.2465 (rough estimate)
• LogP: 3.65590
• Solubility.: Soluble in DMSO;dimethyl formamide

Purity/Quality:

99% ^*data from raw suppliers

Resistomycin ^*data from reagent suppliers

Safty Information:

• Safety Statements: Poison by intraperitoneal route. Moderately toxic by ingestion. Questionable carcinogen with experimental ca"> x." target="_blank">Poison by intraperitoneal route. Moderately toxic by ingestion. Questionable carcinogen with experimental ca

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Resistomycin is a tetrahydroxyantrone has been independently isolated by several groups and reported to have a broad range of biological activities. Resistomycin is active against bacteria, including mycobacteria, and viruses. Resistomycin induces apoptosis and inhibits RNA polymerase. Resistomycin is a tetrahydroxyanthrone that has been independently isolated by several groups and reported to have a broad range of biological activities. Resistomycin is active against bacteria, including mycobacteria, and viruses. Resistomycin induces apoptosis and inhibits RNA polymerase. Resistomycin is an antibiotic RNA polymerase inhibitor and apoptosis inducer.

Technology Process of RESISTOMYCIN

There total 6 articles about RESISTOMYCIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3,5,7,10-tetramethoxy-1,1,9-trimethyl-1H-benzo[cd]pyrene-2,6-dione (22852-03-5) → resistomycin (20004-62-0)

Guidance literature:

With pyridine hydrochloride; at 180 - 190 ℃; for 3.5h;

DOI:10.1021/ja00299a020

Reference yield:

1,3,8-trimethoxy-6-methyl-9,10-anthraquinone (6414-42-2) → resistomycin (20004-62-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 95 percent / Zn / acetic acid / 4 h / Heating

2: 1.) CH₃SO₃H; 2.) CF₃COOH, CF₃SO₃H / 1.) 1,2-dichloroethane, 80 deg C, 5-6 min; 90-95 deg C, 10 h; 2.) 70-80 deg C, 45 min

3: 43 percent / 0.11 M RuO₄ / acetone; CH₂Cl₂ / 2 h / Ambient temperature

4: 90 percent / anhydrous pyridinium hydrochloride / 3.5 h / 180 - 190 °C

With ruthenium tetroxide; methanesulfonic acid; trifluorormethanesulfonic acid; pyridine hydrochloride; trifluoroacetic acid; zinc; In dichloromethane; acetic acid; acetone;

DOI:10.1021/ja00299a020

Reference yield:

9,10-dihydro-1,3,8-trimethoxy-6-methylanthracene (96328-31-3) → resistomycin (20004-62-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) CH₃SO₃H; 2.) CF₃COOH, CF₃SO₃H / 1.) 1,2-dichloroethane, 80 deg C, 5-6 min; 90-95 deg C, 10 h; 2.) 70-80 deg C, 45 min

2: 43 percent / 0.11 M RuO₄ / acetone; CH₂Cl₂ / 2 h / Ambient temperature

3: 90 percent / anhydrous pyridinium hydrochloride / 3.5 h / 180 - 190 °C

With ruthenium tetroxide; methanesulfonic acid; trifluorormethanesulfonic acid; pyridine hydrochloride; trifluoroacetic acid; In dichloromethane; acetone;

DOI:10.1021/ja00299a020

upstream raw materials:

3,5,7,10-tetramethoxy-1,1,9-trimethyl-1H-benzo[cd]pyrene-2,6-dione

1,3,8-trimethoxy-6-methyl-9,10-anthraquinone

9,10-dihydro-1,3,8-trimethoxy-6-methylanthracene

11,11a-dihydro-3,5,7-trimethoxy-1,1,9-trimethyl-2H-benzopyrene-2,10(1H)-dione

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