Benzenesulfonyl-2-(2-chloro-phenyl)-5-(5-methyl-2-pyridin-2-yl-thiazol-4-yl)-1H-indole

Base Information

Chemical Name:Benzenesulfonyl-2-(2-chloro-phenyl)-5-(5-methyl-2-pyridin-2-yl-thiazol-4-yl)-1H-indole
CAS No.:1279106-35-2
Molecular Formula:C₂₉H₂₀ClN₃O₂S₂
Molecular Weight:542.082
Hs Code.:

Synonyms:Benzenesulfonyl-2-(2-chloro-phenyl)-5-(5-methyl-2-pyridin-2-yl-thiazol-4-yl)-1H-indole

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Chemical Property of Benzenesulfonyl-2-(2-chloro-phenyl)-5-(5-methyl-2-pyridin-2-yl-thiazol-4-yl)-1H-indole

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Technology Process of Benzenesulfonyl-2-(2-chloro-phenyl)-5-(5-methyl-2-pyridin-2-yl-thiazol-4-yl)-1H-indole

There total 7 articles about Benzenesulfonyl-2-(2-chloro-phenyl)-5-(5-methyl-2-pyridin-2-yl-thiazol-4-yl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1279105-70-2
trifluoro-methanesulfonic acid 5-methyl-2-pyridin-2-yl-thiazol-4-yl ester

: 1279106-34-1
Benzenesulfonyl-2-(2-chloro-phenyl)-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-indole

: 1279106-35-2
Benzenesulfonyl-2-(2-chloro-phenyl)-5-(5-methyl-2-pyridin-2-yl-thiazol-4-yl)-1H-indole

Guidance literature:: With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; at 100 ℃; for 10h; Sealed;

Reference yield:

: 100-70-9,1232006-36-8
2-Cyanopyridine

: 1279106-35-2
Benzenesulfonyl-2-(2-chloro-phenyl)-5-(5-methyl-2-pyridin-2-yl-thiazol-4-yl)-1H-indole

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / 3 h / 100 °C

1.2: 0.5 h / 25 °C

2.1: sodium hydride / tetrahydrofuran / 0 °C

2.2: 1 h / 25 °C

3.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 10 h / 100 °C / Sealed

With pyridine; sodium hydride; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane;

Reference yield:

: 2142-68-9
1-(2-chlorophenyl)ethanone

: 1279106-35-2
Benzenesulfonyl-2-(2-chloro-phenyl)-5-(5-methyl-2-pyridin-2-yl-thiazol-4-yl)-1H-indole

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium acetate / ethanol / 16 h / 25 °C

2.1: polyphosphoric acid / 70 - 120 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

3.2: 0 - 25 °C

4.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 14 h / 100 °C / Inert atmosphere

5.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 10 h / 100 °C / Sealed

With potassium acetate; sodium hydride; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;