Technology Process of 1,3-dimethoxy-4-(4-methylphenyl)-12-(nitromethyl)-7,10,11,12-tetrahydro-7H-azonino[3,2,1-hi]indole
There total 5 articles about 1,3-dimethoxy-4-(4-methylphenyl)-12-(nitromethyl)-7,10,11,12-tetrahydro-7H-azonino[3,2,1-hi]indole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride;
In
toluene;
for 4.5h;
Inert atmosphere;
Reflux;
DOI:10.1016/j.tet.2011.04.019
- Guidance literature:
-
Multi-step reaction with 3 steps
1: ammonium acetate / isopropyl alcohol / 3 h / Reflux
2: tetrahydrofuran / 72 h / 20 °C / Inert atmosphere
3: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / toluene / 4.5 h / Inert atmosphere; Reflux
With
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; ammonium acetate;
In
tetrahydrofuran; isopropyl alcohol; toluene;
1: Henry reaction / 2: Michael addition;
DOI:10.1016/j.tet.2011.04.019
- Guidance literature:
-
Multi-step reaction with 4 steps
1: potassium hydroxide / dimethyl sulfoxide / 1 h / 20 °C
2: ammonium acetate / isopropyl alcohol / 3 h / Reflux
3: tetrahydrofuran / 72 h / 20 °C / Inert atmosphere
4: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / toluene / 4.5 h / Inert atmosphere; Reflux
With
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; ammonium acetate; potassium hydroxide;
In
tetrahydrofuran; dimethyl sulfoxide; isopropyl alcohol; toluene;
2: Henry reaction / 3: Michael addition;
DOI:10.1016/j.tet.2011.04.019
