2-(4-cyclohexylmethyl-piperazin-1-yl)-ethylamine

Base Information

• Chemical Name: 2-(4-cyclohexylmethyl-piperazin-1-yl)-ethylamine
• CAS No.: 1017442-99-7
• Molecular Formula: C₁₃H₂₇N₃
• Molecular Weight: 225.377
• Mol file: 1017442-99-7.mol

Synonyms:2-(4-cyclohexylmethyl-piperazin-1-yl)-ethylamine

Chemical Property of 2-(4-cyclohexylmethyl-piperazin-1-yl)-ethylamine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-(4-cyclohexylmethyl-piperazin-1-yl)-ethylamine

There total 2 articles about 2-(4-cyclohexylmethyl-piperazin-1-yl)-ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C21H29N3O2 → 2-(4-cyclohexylmethyl-piperazin-1-yl)-ethylamine (1017442-99-7)

Guidance literature:

With hydrazine hydrate; In ethanol; for 3h; Reflux;

DOI:10.1021/acsmedchemlett.8b00177

Reference yield:

1-cyclohexylmethylpiperazine (57184-23-3) → 2-(4-cyclohexylmethyl-piperazin-1-yl)-ethylamine (1017442-99-7)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 3 h / Reflux

2: hydrazine hydrate / ethanol / 3 h / Reflux

With potassium carbonate; hydrazine hydrate; In ethanol; acetonitrile;

DOI:10.1021/acsmedchemlett.8b00177

Reference yield: 21.5%

2-(4-cyclohexylmethyl-piperazin-1-yl)-ethylamine (1017442-99-7) + 3-nitro-5-trifluoromethyl-benzoic acid (328-80-3) → N-(2-(4-(cyclohexylmethyl)piperazin-1-yl)ethyl)-3-nitro-5-(trifluoromethyl)benzamide

Guidance literature:

With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1021/acsmedchemlett.8b00177

upstream raw materials:

1-cyclohexylmethylpiperazine