(11aS)-1,11a-dihydro-10-(2-trimethylsilanylethoxymethyl)-7,8-dimethoxy-2-p-tolyl-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione

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Chemical Name:(11aS)-1,11a-dihydro-10-(2-trimethylsilanylethoxymethyl)-7,8-dimethoxy-2-p-tolyl-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione
CAS No.:489475-05-0
Molecular Formula:C₂₇H₃₄N₂O₅Si
Molecular Weight:494.663
Hs Code.:

Synonyms:(11aS)-1,11a-dihydro-10-(2-trimethylsilanylethoxymethyl)-7,8-dimethoxy-2-p-tolyl-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione

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Chemical Property of (11aS)-1,11a-dihydro-10-(2-trimethylsilanylethoxymethyl)-7,8-dimethoxy-2-p-tolyl-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione

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Technology Process of (11aS)-1,11a-dihydro-10-(2-trimethylsilanylethoxymethyl)-7,8-dimethoxy-2-p-tolyl-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione

There total 8 articles about (11aS)-1,11a-dihydro-10-(2-trimethylsilanylethoxymethyl)-7,8-dimethoxy-2-p-tolyl-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 5720-05-8
4-methylphenylboronic acid

: 260418-07-3
trifluoromethanesulphonic acid (11aS)-1,11a-dihydro-5,11-dioxo-10-(2-trimethylsilanylethoxymethyl)-7,8-dimethoxy-5H-pyrrolo[2,1-c][1,4]benzodiazepine-2-yl ester

: 489475-05-0
(11aS)-1,11a-dihydro-10-(2-trimethylsilanylethoxymethyl)-7,8-dimethoxy-2-p-tolyl-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; water; benzene; at 20 ℃; for 43h;
DOI:10.1021/jm901722v

Reference yield:

: 4998-07-6
4,5-dimethoxy-2-nitro-benzoic acid

: 489475-05-0
(11aS)-1,11a-dihydro-10-(2-trimethylsilanylethoxymethyl)-7,8-dimethoxy-2-p-tolyl-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione

Guidance literature:: Multi-step reaction with 8 steps

1: 57 percent / (COCl)2; TEA / dimethylformamide; CH₂Cl₂ / 20 °C

2: 75 percent / H₂ / 10percent Pd/C / ethanol

3: 95 percent / imidazole / dimethylformamide / 20 °C

4: 77 percent / NaH / dimethylformamide / 0 °C

5: 70 percent / TBAF / tetrahydrofuran / 20 °C

6: 49 percent / (COCl)2; TEA; DMSO / CH₂Cl₂ / -55 °C

7: 60 percent / pyridine / CH₂Cl₂ / 20 °C

8: 66 percent / aq. Na₂CO₃ / Pd(PPh₃)4 / benzene; ethanol / 20 °C

With pyridine; 1H-imidazole; oxalyl dichloride; TEA; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; sodium carbonate; dimethyl sulfoxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; benzene; 6: Swern oxidation;
DOI:10.1039/b205136b

Reference yield:

: 260418-02-8
(2R,11aS)-2-hydroxy-7,8-dimethoxy-1,2,3,10,11,11a-hexahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione

: 489475-05-0
(11aS)-1,11a-dihydro-10-(2-trimethylsilanylethoxymethyl)-7,8-dimethoxy-2-p-tolyl-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / imidazole / dimethylformamide / 20 °C

2: 77 percent / NaH / dimethylformamide / 0 °C

3: 70 percent / TBAF / tetrahydrofuran / 20 °C

4: 49 percent / (COCl)2; TEA; DMSO / CH₂Cl₂ / -55 °C

5: 60 percent / pyridine / CH₂Cl₂ / 20 °C

6: 66 percent / aq. Na₂CO₃ / Pd(PPh₃)4 / benzene; ethanol / 20 °C

With pyridine; 1H-imidazole; oxalyl dichloride; TEA; tetrabutyl ammonium fluoride; sodium hydride; sodium carbonate; dimethyl sulfoxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; benzene; 4: Swern oxidation;
DOI:10.1039/b205136b