methyl (2S,3S)-3-(Boc-amino)-2-<(4-methoxybenzyl)sulfanyl>-6-oxo(tritylamino)hexanoate

Base Information

Chemical Name:methyl (2S,3S)-3-(Boc-amino)-2-<(4-methoxybenzyl)sulfanyl>-6-oxo(tritylamino)hexanoate
CAS No.:222409-82-7
Molecular Formula:C₃₉H₄₄N₂O₆S
Molecular Weight:668.854
Hs Code.:

Synonyms:methyl (2S,3S)-3-(Boc-amino)-2-<(4-methoxybenzyl)sulfanyl>-6-oxo(tritylamino)hexanoate

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Chemical Property of methyl (2S,3S)-3-(Boc-amino)-2-<(4-methoxybenzyl)sulfanyl>-6-oxo(tritylamino)hexanoate

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Technology Process of methyl (2S,3S)-3-(Boc-amino)-2-<(4-methoxybenzyl)sulfanyl>-6-oxo(tritylamino)hexanoate

There total 4 articles about methyl (2S,3S)-3-(Boc-amino)-2-<(4-methoxybenzyl)sulfanyl>-6-oxo(tritylamino)hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 132388-69-3,210750-95-1
Boc-L-Gln(Trt)-OH

: 222409-82-7
methyl (2S,3S)-3-(Boc-amino)-2-<(4-methoxybenzyl)sulfanyl>-6-oxo(tritylamino)hexanoate

Guidance literature:: Multi-step reaction with 5 steps

1: N-methylmorpholine / tetrahydrofuran / 0.33 h / -20 °C

2: 4.45 g / tetrahydrofuran; diethyl ether / 1 h / Ambient temperature

3: silver benzoate, triethylamine / methanol

4: 1.5 h

5: 1.) lithium diisopropylamide / 1.) THF, heptane, ethylbenzene, -78 deg C, 30 min, 2.) THF, heptane, ethylbenzene, 2 h

With 4-methyl-morpholine; silver benzoate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether;
DOI:10.1021/jm981066w

Reference yield:

: C₃₄H₄₀N₂O₇

: 222409-82-7
methyl (2S,3S)-3-(Boc-amino)-2-<(4-methoxybenzyl)sulfanyl>-6-oxo(tritylamino)hexanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 4.45 g / tetrahydrofuran; diethyl ether / 1 h / Ambient temperature

2: silver benzoate, triethylamine / methanol

3: 1.5 h

4: 1.) lithium diisopropylamide / 1.) THF, heptane, ethylbenzene, -78 deg C, 30 min, 2.) THF, heptane, ethylbenzene, 2 h

With silver benzoate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether;
DOI:10.1021/jm981066w

Reference yield:

: {3-diazo-2-oxo-1-[2-(trityl-carbamoyl)-ethyl]-propyl}-carbamic acid tert-butyl ester

: 222409-82-7
methyl (2S,3S)-3-(Boc-amino)-2-<(4-methoxybenzyl)sulfanyl>-6-oxo(tritylamino)hexanoate

Guidance literature:: Multi-step reaction with 3 steps

1: silver benzoate, triethylamine / methanol

2: 1.5 h

3: 1.) lithium diisopropylamide / 1.) THF, heptane, ethylbenzene, -78 deg C, 30 min, 2.) THF, heptane, ethylbenzene, 2 h

With silver benzoate; triethylamine; lithium diisopropyl amide; In methanol;
DOI:10.1021/jm981066w