(4-Bromo-3-chlorophenyl)hydrazine hydrochloride

Base Information

• Chemical Name: (4-Bromo-3-chlorophenyl)hydrazine hydrochloride
• CAS No.: 1177361-07-7
• Molecular Formula: C₆H₆BrClN₂*ClH
• Molecular Weight: 257.945
• European Community (EC) Number: 854-783-6
• Mol file: 1177361-07-7.mol

Synonyms:1177361-07-7;(4-bromo-3-chlorophenyl)hydrazine hydrochloride;1-(4-Bromo-3-chlorophenyl)hydrazine, HCl;1-(4-Bromo-3-chlorophenyl)hydrazine hydrochloride;(4-bromo-3-chlorophenyl)hydrazine;hydrochloride;MFCD05256440;(4-Bromo-3-chloro-phenyl)-hydrazine hydrochloride;SCHEMBL4052903;ZIGPVBYXYLWEHA-UHFFFAOYSA-N;AKOS005143663;(4-Bromo-3-Chlorophenyl)hydrazine HCl;BS-14504;SY260981;CS-0196533;(4-bromo-3-chlorophenyl)hydrazinehydrochloride;F17062;EN300-6502200

Chemical Property of (4-Bromo-3-chlorophenyl)hydrazine hydrochloride

Chemical Property:

• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 255.91697
• Heavy Atom Count: 11
• Complexity: 112

Purity/Quality:

97% ^*data from raw suppliers

(4-Bromo-3-Chlorophenyl)hydrazinehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=C(C=C1NN)Cl)Br.Cl

Technology Process of (4-Bromo-3-chlorophenyl)hydrazine hydrochloride

There total 2 articles about (4-Bromo-3-chlorophenyl)hydrazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-bromo-3-chloroaniline (21402-26-6) → (4-bromo-3-chlorophenyl)hydrazine hydrochloride (1177361-07-7)

Guidance literature:

4-bromo-3-chloroaniline; With hydrogenchloride; sodium nitrite; In water; for 0.75h; Cooling with ice;

With tin(II) chloride dihdyrate; In water; at 20 ℃;

Reference yield:

1-bromo-2-chloro-4-nitrobenzene (29682-39-1) → (4-bromo-3-chlorophenyl)hydrazine hydrochloride (1177361-07-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tin(II) chloride dihdyrate; hydrogenchloride / ethanol / 9 h / 80 °C

2.1: hydrogenchloride / 1 h / 0 °C

2.2: 3.5 h / 0 °C

2.3: 0 - 20 °C

With hydrogenchloride; tin(II) chloride dihdyrate; In ethanol;

DOI:10.1016/j.bioorg.2021.105172

Reference yield:

(4-bromo-3-chlorophenyl)hydrazine hydrochloride (1177361-07-7) → 7-chloro-6-(2'-hydroxy-[1,1'-biphenyl]-4-yl)-2,3,4,9-tetrahydro-1H-carbazole-3-carboxylic acid

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid / 80 °C / Inert atmosphere

2: potassium carbonate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride / toluene; ethanol; tetrahydrofuran / 2 h / Inert atmosphere; Heating

3: sodium hydroxide; methanol / 70 °C

With methanol; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium carbonate; acetic acid; sodium hydroxide; In tetrahydrofuran; ethanol; toluene; 2: |Suzuki-Miyaura Coupling;

DOI:10.1016/j.bioorg.2021.105172

upstream raw materials:

4-bromo-3-chloroaniline

1-bromo-2-chloro-4-nitrobenzene