(S,S)-(+)-1-(2-t-butylthio-3-cyclohexyl-1-propylidenamino)-2-methoxymethyl-pyrrolidine

Base Information

Chemical Name:(S,S)-(+)-1-(2-t-butylthio-3-cyclohexyl-1-propylidenamino)-2-methoxymethyl-pyrrolidine
CAS No.:155996-81-9
Molecular Formula:C₁₉H₃₆N₂OS
Molecular Weight:340.574
Hs Code.:

Synonyms:(S,S)-(+)-1-(2-t-butylthio-3-cyclohexyl-1-propylidenamino)-2-methoxymethyl-pyrrolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S,S)-(+)-1-(2-t-butylthio-3-cyclohexyl-1-propylidenamino)-2-methoxymethyl-pyrrolidine

Chemical Property:

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Technology Process of (S,S)-(+)-1-(2-t-butylthio-3-cyclohexyl-1-propylidenamino)-2-methoxymethyl-pyrrolidine

There total 2 articles about (S,S)-(+)-1-(2-t-butylthio-3-cyclohexyl-1-propylidenamino)-2-methoxymethyl-pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 59983-39-0,187035-29-6
(S)-1-amino-2-(methoxymethyl)pyrrolidine

: 155996-81-9
(S,S)-(+)-1-(2-t-butylthio-3-cyclohexyl-1-propylidenamino)-2-methoxymethyl-pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) 6N HCl; 2.) MgSO₄, 4 Angstroem molecular sieves / 1.) cyclohexane, reflux, 2 h; 2.) ether

2: 1.) LDA / 1.) THF, 5 h, 0 deg C; 2.) THF, -100 deg C, 1 h

With hydrogenchloride; 4 A molecular sieve; magnesium sulfate; lithium diisopropyl amide;
DOI:10.1016/S0040-4020(01)87015-0

Reference yield:

: 155996-65-9
(2S)-(-)-[2-(tert-butylsulfanyl)ethylidene][2-(methoxymethyl)pyrrolidin-1-yl]amine

: 155996-81-9
(S,S)-(+)-1-(2-t-butylthio-3-cyclohexyl-1-propylidenamino)-2-methoxymethyl-pyrrolidine

: (S,R)-1-(2-t-butylthio-3-cyclohexyl-1-propylidenamino)-2-methoxymethyl-pyrrolidine

Guidance literature:: With lithium diisopropyl amide; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; 1.) THF, 5 h, 0 deg C; 2.) THF, -100 deg C, 1 h;
DOI:10.1016/S0040-4020(01)87015-0

Reference yield:

: 155996-81-9
(S,S)-(+)-1-(2-t-butylthio-3-cyclohexyl-1-propylidenamino)-2-methoxymethyl-pyrrolidine

: 155996-75-1
(S)-(+)-2-t-butylthio-3-cyclohexyl-propanal

: (R)-(-)-2-t-butylthio-3-cyclohexyl-propanal

Guidance literature:: With ozone; In dichloromethane; at -78 ℃; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1016/S0040-4020(01)87015-0