(R)-3-fluoro-2-cyanophenyl (2-(difluoromethyl)pyridin-4-yl) N-tert-butylsulfinyl imine

Base Information

Chemical Name:(R)-3-fluoro-2-cyanophenyl (2-(difluoromethyl)pyridin-4-yl) N-tert-butylsulfinyl imine
CAS No.:1349036-94-7
Molecular Formula:C₁₈H₁₆F₃N₃OS
Molecular Weight:379.406
Hs Code.:

Synonyms:(R)-3-fluoro-2-cyanophenyl (2-(difluoromethyl)pyridin-4-yl) N-tert-butylsulfinyl imine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-3-fluoro-2-cyanophenyl (2-(difluoromethyl)pyridin-4-yl) N-tert-butylsulfinyl imine

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Technology Process of (R)-3-fluoro-2-cyanophenyl (2-(difluoromethyl)pyridin-4-yl) N-tert-butylsulfinyl imine

There total 3 articles about (R)-3-fluoro-2-cyanophenyl (2-(difluoromethyl)pyridin-4-yl) N-tert-butylsulfinyl imine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.9%

: 1349036-90-3
3-fluoro-2-cyanophenyl (2-(difluoromethyl)pyridin-4-yl) ketone

: 196929-78-9
(R)-2-methylpropane-2-sulfinamide

: 1349036-94-7
(R)-3-fluoro-2-cyanophenyl (2-(difluoromethyl)pyridin-4-yl) N-tert-butylsulfinyl imine

Guidance literature:: With titanium(IV) tetraethanolate; In 2-methyltetrahydrofuran; for 3h; Reflux;

Reference yield:

: 1256818-14-0
2-(difluoromethyl)isonicotinic acid

: 1349036-94-7
(R)-3-fluoro-2-cyanophenyl (2-(difluoromethyl)pyridin-4-yl) N-tert-butylsulfinyl imine

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / toluene / 40 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / -15 °C

2.2: 18.08 h / -15 - 0 °C

3.1: titanium(IV) tetraethanolate / 2-methyltetrahydrofuran / 3 h / Reflux

With titanium(IV) tetraethanolate; oxalyl dichloride; isopropylmagnesium chloride; N,N-dimethyl-formamide; In tetrahydrofuran; 2-methyltetrahydrofuran; toluene;

Reference yield:

: 1225047-28-8
2-(difluoromethyl)isonicotinoyl chloride

: 1349036-94-7
(R)-3-fluoro-2-cyanophenyl (2-(difluoromethyl)pyridin-4-yl) N-tert-butylsulfinyl imine

Guidance literature:: Multi-step reaction with 2 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / -15 °C

1.2: 18.08 h / -15 - 0 °C

2.1: titanium(IV) tetraethanolate / 2-methyltetrahydrofuran / 3 h / Reflux

With titanium(IV) tetraethanolate; isopropylmagnesium chloride; In tetrahydrofuran; 2-methyltetrahydrofuran;