2-(tert-Butyl-diphenyl-silanyloxy)-6-((2S,4S,6R)-4-hydroxy-6-methoxymethyl-tetrahydro-pyran-2-ylmethyl)-benzoic acid methyl ester

Base Information

Chemical Name:2-(tert-Butyl-diphenyl-silanyloxy)-6-((2S,4S,6R)-4-hydroxy-6-methoxymethyl-tetrahydro-pyran-2-ylmethyl)-benzoic acid methyl ester
CAS No.:674336-01-7
Molecular Formula:C₃₂H₄₀O₆Si
Molecular Weight:548.751
Hs Code.:

Synonyms:2-(tert-Butyl-diphenyl-silanyloxy)-6-((2S,4S,6R)-4-hydroxy-6-methoxymethyl-tetrahydro-pyran-2-ylmethyl)-benzoic acid methyl ester

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Chemical Property of 2-(tert-Butyl-diphenyl-silanyloxy)-6-((2S,4S,6R)-4-hydroxy-6-methoxymethyl-tetrahydro-pyran-2-ylmethyl)-benzoic acid methyl ester

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Technology Process of 2-(tert-Butyl-diphenyl-silanyloxy)-6-((2S,4S,6R)-4-hydroxy-6-methoxymethyl-tetrahydro-pyran-2-ylmethyl)-benzoic acid methyl ester

There total 1 articles about 2-(tert-Butyl-diphenyl-silanyloxy)-6-((2S,4S,6R)-4-hydroxy-6-methoxymethyl-tetrahydro-pyran-2-ylmethyl)-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 2-(tert-Butyl-diphenyl-silanyloxy)-6-((2S,4S)-2-methoxymethyl-3,7-dioxa-bicyclo[4.1.0]hept-4-ylmethyl)-benzoic acid methyl ester

: 674336-01-7
2-(tert-Butyl-diphenyl-silanyloxy)-6-((2S,4S,6R)-4-hydroxy-6-methoxymethyl-tetrahydro-pyran-2-ylmethyl)-benzoic acid methyl ester

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; at -78 ℃; for 0.666667h;
DOI:10.1021/ja037957x

Reference yield: 70.0%

: 79-11-8
chloroacetic acid

: 674336-01-7
2-(tert-Butyl-diphenyl-silanyloxy)-6-((2S,4S,6R)-4-hydroxy-6-methoxymethyl-tetrahydro-pyran-2-ylmethyl)-benzoic acid methyl ester

: 674336-02-8
2-(tert-Butyl-diphenyl-silanyloxy)-6-[(2S,4R,6R)-4-(2-chloro-acetoxy)-6-methoxymethyl-tetrahydro-pyran-2-ylmethyl]-benzoic acid methyl ester

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In toluene; at 0 - 25 ℃; for 16h;
DOI:10.1021/ja037957x

Reference yield:

: 674336-01-7
2-(tert-Butyl-diphenyl-silanyloxy)-6-((2S,4S,6R)-4-hydroxy-6-methoxymethyl-tetrahydro-pyran-2-ylmethyl)-benzoic acid methyl ester

: (1S,11S,13R,15R)-15-Benzyloxy-11-((Z)-3-iodo-allyl)-7-methoxymethoxy-10,17-dioxa-tricyclo[11.3.1.0^3,8]heptadeca-3⁽⁸⁾,4,6-trien-9-one

Guidance literature:: Multi-step reaction with 17 steps

1.1: 70 percent / PPh₃; DIAD / toluene / 16 h / 0 - 25 °C

2.1: 88 percent / 15-crown-5; NaI; BBr₃ / CH₂Cl₂ / 1 h / -30 °C

3.1: 95 percent / 2,6-lutidine / CH₂Cl₂ / 4 h / -78 - 20 °C

4.1: 95 percent / K₂CO₃; methanol / 0.17 h / 20 °C

5.1: 93 percent / TfOH / diethyl ether / 4 h / 20 °C

6.1: 95 percent / HCl / methanol / 0.17 h / 20 °C

7.1: 93 percent / PCC / CH₂Cl₂ / 4 h

8.1: LHMDS / tetrahydrofuran / -78 - 25 °C

8.2: tetrahydrofuran / 18 h / -78 - 25 °C

9.1: 1.19 g / Hg(OAc)2; aq. KI / tetrahydrofuran; H₂O / 0.5 h

10.1: 75 percent / diethyl ether / 4 h / -78 °C

11.1: 95 percent / aq. LiOH*H₂O / methanol; tetrahydrofuran / 6 h / Heating

12.1: 80 percent / Et₃N / acetone / 48 h / 52 °C

13.1: 90 percent / Bu₄NI; aq. NaOH / CH₂Cl₂ / 3 h / 20 °C

14.1: 63 percent / NaH / tetrahydrofuran / 4 h / Heating

15.1: NMO; OsO₄ / acetone; H₂O; toluene / 4 h / 20 °C

16.1: aq. NaIO₄ / tetrahydrofuran / 2 h / 20 °C

17.1: CrCl₂ / tetrahydrofuran; dioxane / 24 h

With 2,6-dimethylpyridine; chromium dichloride; hydrogenchloride; methanol; lithium hydroxide; sodium hydroxide; sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone; 15-crown-5; trifluorormethanesulfonic acid; di-isopropyl azodicarboxylate; mercury(II) diacetate; boron tribromide; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; triethylamine; triphenylphosphine; pyridinium chlorochromate; potassium iodide; sodium iodide; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; water; acetone; toluene; 1.1: Mitsunobu reaction;
DOI:10.1021/ja037957x