1-(1-(4-(2-morpholinoethoxy)phenyl)-3-(trimethylsilyl)-1H-pyrazol-5-yl)-3-(4-((2-(phenylamino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

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Chemical Name:1-(1-(4-(2-morpholinoethoxy)phenyl)-3-(trimethylsilyl)-1H-pyrazol-5-yl)-3-(4-((2-(phenylamino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea
CAS No.:1571073-57-8
Molecular Formula:C₃₉H₄₂N₈O₄Si
Molecular Weight:714.899
Hs Code.:

Synonyms:1-(1-(4-(2-morpholinoethoxy)phenyl)-3-(trimethylsilyl)-1H-pyrazol-5-yl)-3-(4-((2-(phenylamino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

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Chemical Property of 1-(1-(4-(2-morpholinoethoxy)phenyl)-3-(trimethylsilyl)-1H-pyrazol-5-yl)-3-(4-((2-(phenylamino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

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Technology Process of 1-(1-(4-(2-morpholinoethoxy)phenyl)-3-(trimethylsilyl)-1H-pyrazol-5-yl)-3-(4-((2-(phenylamino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

There total 5 articles about 1-(1-(4-(2-morpholinoethoxy)phenyl)-3-(trimethylsilyl)-1H-pyrazol-5-yl)-3-(4-((2-(phenylamino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1379401-24-7
4-((4-aminonaphthalen-1-yl)oxy)-N-phenylpyrimidin-2-amine

: 1571073-86-3
1-(4-(2-morpholinoethoxy)phenyl)-3-(trimethylsilyl)-1H-pyrazole-5-carboxylic acid

: 1571073-57-8
1-(1-(4-(2-morpholinoethoxy)phenyl)-3-(trimethylsilyl)-1H-pyrazol-5-yl)-3-(4-((2-(phenylamino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

Guidance literature:: 1-(4-(2-morpholinoethoxy)phenyl)-3-(trimethylsilyl)-1H-pyrazole-5-carboxylic acid; With diphenyl phosphoryl azide; triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1.5h; Inert atmosphere;

4-((4-aminonaphthalen-1-yl)oxy)-N-phenylpyrimidin-2-amine; In N,N-dimethyl-formamide; at 100 ℃; for 1h;

Reference yield:

: 36960-47-1
ethyl 3-(trimethylsilyl)-1H-pyrazole-5-carboxylate

: 1571073-57-8
1-(1-(4-(2-morpholinoethoxy)phenyl)-3-(trimethylsilyl)-1H-pyrazol-5-yl)-3-(4-((2-(phenylamino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine; copper diacetate / dichloromethane / 18 h / 20 °C / Molecular sieve

2.1: sodium hydroxide; ethanol / 4 h / 20 °C

3.1: triethylamine; diphenyl phosphoryl azide / N,N-dimethyl-formamide / 1.5 h / 0 - 20 °C / Inert atmosphere

3.2: 1 h / 100 °C

With pyridine; ethanol; diphenyl phosphoryl azide; copper diacetate; triethylamine; sodium hydroxide; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1571073-77-2
ethyl 1-(6-methoxypyridin-3-yl)-3-(trimethylsilyl)-1H-pyrazole-5-carboxylate

: 1571073-57-8
1-(1-(4-(2-morpholinoethoxy)phenyl)-3-(trimethylsilyl)-1H-pyrazol-5-yl)-3-(4-((2-(phenylamino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; ethanol / 4 h / 20 °C

2.1: triethylamine; diphenyl phosphoryl azide / N,N-dimethyl-formamide / 1.5 h / 0 - 20 °C / Inert atmosphere

2.2: 1 h / 100 °C

With ethanol; diphenyl phosphoryl azide; triethylamine; sodium hydroxide; In N,N-dimethyl-formamide;