N-((1R,2S)-1-(4-(6-(2-amino-1,1-difluoro-2-oxoethyl)pyridin-3-yl)phenyl)-3-fluoro-1-hydroxypropan-2-yl)-2,2-difluoroacetamide

Base Information

• Chemical Name: N-((1R,2S)-1-(4-(6-(2-amino-1,1-difluoro-2-oxoethyl)pyridin-3-yl)phenyl)-3-fluoro-1-hydroxypropan-2-yl)-2,2-difluoroacetamide
• CAS No.: 1582262-00-7
• Molecular Formula: C₁₈H₁₆F₅N₃O₃
• Molecular Weight: 417.335
• Mol file: 1582262-00-7.mol

Synonyms:N-((1R,2S)-1-(4-(6-(2-amino-1,1-difluoro-2-oxoethyl)pyridin-3-yl)phenyl)-3-fluoro-1-hydroxypropan-2-yl)-2,2-difluoroacetamide

Chemical Property of N-((1R,2S)-1-(4-(6-(2-amino-1,1-difluoro-2-oxoethyl)pyridin-3-yl)phenyl)-3-fluoro-1-hydroxypropan-2-yl)-2,2-difluoroacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-((1R,2S)-1-(4-(6-(2-amino-1,1-difluoro-2-oxoethyl)pyridin-3-yl)phenyl)-3-fluoro-1-hydroxypropan-2-yl)-2,2-difluoroacetamide

There total 2 articles about N-((1R,2S)-1-(4-(6-(2-amino-1,1-difluoro-2-oxoethyl)pyridin-3-yl)phenyl)-3-fluoro-1-hydroxypropan-2-yl)-2,2-difluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2-difluoro-N-((1R,2S)-3-fluoro-1-hydroxy-1-(4-(trimethylstannyl)phenyl)propan-2-yl)acetamide (1454906-65-0) + 2-(5-bromopyridin-2-yl)-2,2-difluoroacetamide (1582262-93-8) → N-((1R,2S)-1-(4-(6-(2-amino-1,1-difluoro-2-oxoethyl)pyridin-3-yl)phenyl)-3-fluoro-1-hydroxypropan-2-yl)-2,2-difluoroacetamide (1582262-00-7)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; trifuran-2-yl-phosphane; In 1-methyl-pyrrolidin-2-one; at 80 ℃; for 16h; Inert atmosphere;

Reference yield:

tert-butyl-2-(5-bromopyridin-2-yl)-2,2-difluoroacetate (1582262-94-9) → N-((1R,2S)-1-(4-(6-(2-amino-1,1-difluoro-2-oxoethyl)pyridin-3-yl)phenyl)-3-fluoro-1-hydroxypropan-2-yl)-2,2-difluoroacetamide (1582262-00-7)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonia / methanol / 72 h / 20 °C

2: trifuran-2-yl-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1-methyl-pyrrolidin-2-one / 16 h / 80 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; trifuran-2-yl-phosphane; ammonia; In 1-methyl-pyrrolidin-2-one; methanol;

upstream raw materials:

2,2-difluoro-N-((1R,2S)-3-fluoro-1-hydroxy-1-(4-(trimethylstannyl)phenyl)propan-2-yl)acetamide

2-(5-bromopyridin-2-yl)-2,2-difluoroacetamide

tert-butyl-2-(5-bromopyridin-2-yl)-2,2-difluoroacetate