2-benzyl-5-chloro-8-methoxy-1,2,3,4-tetrahydrobenzo[b][1,7]naphthyridine

Base Information

• Chemical Name: 2-benzyl-5-chloro-8-methoxy-1,2,3,4-tetrahydrobenzo[b][1,7]naphthyridine
• CAS No.: 214551-73-2
• Molecular Formula: C₂₀H₁₉ClN₂O
• Molecular Weight: 338.837

Synonyms:2-benzyl-5-chloro-8-methoxy-1,2,3,4-tetrahydrobenzo[b][1,7]naphthyridine

Chemical Property of 2-benzyl-5-chloro-8-methoxy-1,2,3,4-tetrahydrobenzo[b][1,7]naphthyridine

Chemical Property:

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Technology Process of 2-benzyl-5-chloro-8-methoxy-1,2,3,4-tetrahydrobenzo[b][1,7]naphthyridine

There total 4 articles about 2-benzyl-5-chloro-8-methoxy-1,2,3,4-tetrahydrobenzo[b][1,7]naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-benzyl-8-methoxy-1,2,3,4-tetrahydrobenzo[b][1,7]naphthyridin-5(10H)-one (214551-68-5) → 2-benzyl-5-chloro-8-methoxy-1,2,3,4-tetrahydrobenzo[b][1,7]naphthyridine (214551-73-2)

Guidance literature:

With trichlorophosphate; at 50 ℃; for 0.5h;

DOI:10.1002/jhet.5570350422

Reference yield:

ethyl 1-benzyl-3-oxo-4-piperidinecarboxylate (39514-19-7) → 2-benzyl-5-chloro-8-methoxy-1,2,3,4-tetrahydrobenzo[b][1,7]naphthyridine (214551-73-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 53 percent / p-toluenesulfonic acid monohydrate / toluene / 8 h / Heating

2: 54 percent / diphenyl ether / Heating

3: 90 percent / POCl₃ / 0.5 h / 50 °C

With toluene-4-sulfonic acid; trichlorophosphate; In diphenylether; toluene;

DOI:10.1002/jhet.5570350422

Reference yield:

m-Anisidine (536-90-3,918666-97-4) → 2-benzyl-5-chloro-8-methoxy-1,2,3,4-tetrahydrobenzo[b][1,7]naphthyridine (214551-73-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 53 percent / p-toluenesulfonic acid monohydrate / toluene / 8 h / Heating

2: 54 percent / diphenyl ether / Heating

3: 90 percent / POCl₃ / 0.5 h / 50 °C

With toluene-4-sulfonic acid; trichlorophosphate; In diphenylether; toluene;

DOI:10.1002/jhet.5570350422

upstream raw materials:

2-benzyl-8-methoxy-1,2,3,4-tetrahydrobenzo[b][1,7]naphthyridin-5(10H)-one

ethyl 1-benzyl-3-oxo-4-piperidinecarboxylate

m-Anisidine

1-Benzyl-5-(3-methoxy-phenylamino)-1,2,3,6-tetrahydro-pyridine-4-carboxylic acid ethyl ester

Downstream raw materials:

5-amino-2-benzyl-8-methoxy-1,2,3,4-tetrahydrobenzo[b][1,7]naphthyridine

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