(S)-N-(6-benzyloxy-2,3-dihydrobenzofuran-3-yl)hydroxylamine

Base Information

• Chemical Name: (S)-N-(6-benzyloxy-2,3-dihydrobenzofuran-3-yl)hydroxylamine
• CAS No.: 162750-07-4
• Molecular Formula: C₁₅H₁₅NO₃
• Molecular Weight: 257.289
• Mol file: 162750-07-4.mol

Synonyms:(S)-N-(6-benzyloxy-2,3-dihydrobenzofuran-3-yl)hydroxylamine

Chemical Property of (S)-N-(6-benzyloxy-2,3-dihydrobenzofuran-3-yl)hydroxylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N-(6-benzyloxy-2,3-dihydrobenzofuran-3-yl)hydroxylamine

There total 5 articles about (S)-N-(6-benzyloxy-2,3-dihydrobenzofuran-3-yl)hydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.4%

N-(6-Benzyloxy-2,3-dihydro-benzofuran-3-yl)-N-[(3aS,6R,6aS)-6-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-hydroxylamine → 2,3:5,6-di-O-isopropylidene-D-mannose oxime (35023-80-4) + (S)-N-(6-benzyloxy-2,3-dihydrobenzofuran-3-yl)hydroxylamine (162750-07-4)

Guidance literature:

With hydroxylamine hydrochloride; sodium hydrogencarbonate; In ethanol; water; for 1.33333h; Heating;

DOI:10.1021/jo9621736

Reference yield:

4-benzoxy-salicylaldehyde (52085-14-0) → (S)-N-(6-benzyloxy-2,3-dihydrobenzofuran-3-yl)hydroxylamine (162750-07-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / (n-Bu)3N / toluene / 6 h / Heating

2: 2.) hydroxylamine hydrochloride, NaHCO₃ / 1.) toluene, THF, -10 - 10 deg C; 2.)H₂O, ethanol

With tributyl-amine; hydroxylamine hydrochloride; sodium hydrogencarbonate; In toluene;

DOI:10.1016/0040-4039(96)00922-7

Reference yield:

C23H21NO4 → (S)-N-(6-benzyloxy-2,3-dihydrobenzofuran-3-yl)hydroxylamine (162750-07-4)

Guidance literature:

With hydrogenchloride; In diethyl ether; for 20h;

DOI:10.1016/j.tetasy.2008.03.008

upstream raw materials:

dimethylsulfoxonium methylide

N-(2,3:5,6-di-O-isopropylidene-α-D-mannofuranosyl)[2-hydroxy-4-(phenylmethoxy)phenyl]methanimine N-oxide

4-benzoxy-salicylaldehyde

Downstream raw materials:

6-benzyloxy-benzofuran