1-((tert-butoxy)carbonyl)-2-(4-oxopentyl)-4-(phenylsulfonyl)-1,2,5,6-tetrahydropyridine

Base Information

Chemical Name:1-((tert-butoxy)carbonyl)-2-(4-oxopentyl)-4-(phenylsulfonyl)-1,2,5,6-tetrahydropyridine
CAS No.:1420779-25-4
Molecular Formula:C₂₁H₂₉NO₅S
Molecular Weight:407.531
Hs Code.:

Synonyms:1-((tert-butoxy)carbonyl)-2-(4-oxopentyl)-4-(phenylsulfonyl)-1,2,5,6-tetrahydropyridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-((tert-butoxy)carbonyl)-2-(4-oxopentyl)-4-(phenylsulfonyl)-1,2,5,6-tetrahydropyridine

Chemical Property:

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Technology Process of 1-((tert-butoxy)carbonyl)-2-(4-oxopentyl)-4-(phenylsulfonyl)-1,2,5,6-tetrahydropyridine

There total 8 articles about 1-((tert-butoxy)carbonyl)-2-(4-oxopentyl)-4-(phenylsulfonyl)-1,2,5,6-tetrahydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1420779-24-3
1-((tert-butoxy)carbonyl)-2-[(E)-4-oxopent-2-enyl]-4-(phenylsulfonyl)-1,2,5,6-tetrahydropyridine

: 1420779-25-4
1-((tert-butoxy)carbonyl)-2-(4-oxopentyl)-4-(phenylsulfonyl)-1,2,5,6-tetrahydropyridine

Guidance literature:: With platinum(IV) oxide; hydrogen; In ethyl acetate; at 20 ℃; for 21h;
DOI:10.1016/j.tet.2012.12.017

Reference yield:

: 411240-92-1
4-phenylsulfanyl-5,6-dihydro-1H-pyridin-2-one

: 1420779-25-4
1-((tert-butoxy)carbonyl)-2-(4-oxopentyl)-4-(phenylsulfonyl)-1,2,5,6-tetrahydropyridine

Guidance literature:: Multi-step reaction with 7 steps

1.1: dmap; triethylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane; water / 2 h / 20 °C

3.1: dichloromethane; tetrahydrofuran / -78 °C

4.1: boron trifluoride diethyl etherate / dichloromethane / 0.5 h / -78 °C

4.2: -78 - 20 °C

5.1: dmap; triethylamine / dichloromethane / 4 h / Inert atmosphere; Reflux

6.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / toluene / 7 h / Reflux

7.1: hydrogen; platinum(IV) oxide / ethyl acetate / 21 h / 20 °C

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; dmap; platinum(IV) oxide; boron trifluoride diethyl etherate; hydrogen; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; water; ethyl acetate; toluene;
DOI:10.1016/j.tet.2012.12.017

Reference yield:

: 1420779-10-7
2-allyl-4-(phenylsulfonyl)-1,2,5,6-tetrahydropyridine

: 1420779-25-4
1-((tert-butoxy)carbonyl)-2-(4-oxopentyl)-4-(phenylsulfonyl)-1,2,5,6-tetrahydropyridine

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; triethylamine / dichloromethane / 4 h / Inert atmosphere; Reflux

2: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / toluene / 7 h / Reflux

3: hydrogen; platinum(IV) oxide / ethyl acetate / 21 h / 20 °C

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; dmap; platinum(IV) oxide; hydrogen; triethylamine; In dichloromethane; ethyl acetate; toluene;
DOI:10.1016/j.tet.2012.12.017