[7-(3-chloro-4-fluoro-phenyl)-5-(4-methoxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-hydrazine

Base Information

• Chemical Name: [7-(3-chloro-4-fluoro-phenyl)-5-(4-methoxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-hydrazine
• CAS No.: 243666-08-2
• Molecular Formula: C₁₉H₁₅ClFN₅O
• Molecular Weight: 383.812

Synonyms:[7-(3-chloro-4-fluoro-phenyl)-5-(4-methoxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-hydrazine

Chemical Property of [7-(3-chloro-4-fluoro-phenyl)-5-(4-methoxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-hydrazine

Chemical Property:

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Technology Process of [7-(3-chloro-4-fluoro-phenyl)-5-(4-methoxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-hydrazine

There total 7 articles about [7-(3-chloro-4-fluoro-phenyl)-5-(4-methoxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

4-chloro-7-(3-chloro-4-fluoro-phenyl)-5-(4-methoxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidine (243666-02-6) → [7-(3-chloro-4-fluoro-phenyl)-5-(4-methoxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-hydrazine (243666-08-2)

Guidance literature:

With hydrazine hydrate; In ethanol; Heating;

DOI:10.1002/jhet.5570360325 DOI:10.1002/hc.20295

Reference yield: 66.0%

1-(3-chloro-4-fluorophenyl)-N-ethoxymethylene-2-amino-3-cyano-4-(4-methoxyphenyl)pyrrole (1006628-53-0) → [7-(3-chloro-4-fluoro-phenyl)-5-(4-methoxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-hydrazine (243666-08-2)

Guidance literature:

With hydrazine hydrate; In ethanol; at 60 - 65 ℃;

DOI:10.1002/hc.20295

Reference yield:

2-amino-1-(3-chloro-4-fluoro-phenyl)-4-(4-methoxy-phenyl)-1H-pyrrole-3-carbonitrile (243665-84-1) → [7-(3-chloro-4-fluoro-phenyl)-5-(4-methoxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-hydrazine (243666-08-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / Heating

2: 77 percent / hydrazine hydrate / methanol / Heating

3: hydrazine hydrate / ethanol / Heating

With hydrazine hydrate; In methanol; ethanol;

DOI:10.1002/hc.20295

upstream raw materials:

4-chloro-7-(3-chloro-4-fluoro-phenyl)-5-(4-methoxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidine

1-(3-chloro-4-fluorophenyl)-N-ethoxymethylene-2-amino-3-cyano-4-(4-methoxyphenyl)pyrrole

3-amino-4-imino-5-(4-methoxyphenyl)-7-(3-chloro-4-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine

2-amino-1-(3-chloro-4-fluoro-phenyl)-4-(4-methoxy-phenyl)-1H-pyrrole-3-carbonitrile

Downstream raw materials:

7-(3-chloro-4-fluorophenyl)-9-(4-methoxyphenyl)-7H-pyrrolo[3,2-e][1,2,4]triazolo[4,3-c]pyrimidine

7-(3-chloro-4-fluorophenyl)-9-(4-methoxyphenyl)tetrazolo[1,5-c]-7H-pyrrolo[3,2-e]pyrimidine

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