1,1-dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-(N-{(R)-α-[N-((S)-1-carboxy-(R)-2-hydroxyprop-1-yl)carbamoyl]-4-hydroxybenzyl}carbamoylmethoxy)-2,3,4,5-tetrahydro-1,2,5-benzothiadiazepine

Base Information

Chemical Name:1,1-dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-(N-{(R)-α-[N-((S)-1-carboxy-(R)-2-hydroxyprop-1-yl)carbamoyl]-4-hydroxybenzyl}carbamoylmethoxy)-2,3,4,5-tetrahydro-1,2,5-benzothiadiazepine
CAS No.:501692-40-6
Molecular Formula:C₃₇H₄₈N₄O₉S₂
Molecular Weight:756.942
Hs Code.:

1,1-dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-(N-{(R)-α-[N-((S)-1-carboxy-(R)-2-hydroxyprop-1-yl)carbamoyl]-4-hydroxybenzyl}carbamoylmethoxy)-2,3,4,5-tetrahydro-1,2,5-benzothiadiazepine

Synonyms:1,1-dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-(N-{(R)-α-[N-((S)-1-carboxy-(R)-2-hydroxyprop-1-yl)carbamoyl]-4-hydroxybenzyl}carbamoylmethoxy)-2,3,4,5-tetrahydro-1,2,5-benzothiadiazepine

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Chemical Property of 1,1-dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-(N-{(R)-α-[N-((S)-1-carboxy-(R)-2-hydroxyprop-1-yl)carbamoyl]-4-hydroxybenzyl}carbamoylmethoxy)-2,3,4,5-tetrahydro-1,2,5-benzothiadiazepine

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Technology Process of 1,1-dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-(N-{(R)-α-[N-((S)-1-carboxy-(R)-2-hydroxyprop-1-yl)carbamoyl]-4-hydroxybenzyl}carbamoylmethoxy)-2,3,4,5-tetrahydro-1,2,5-benzothiadiazepine

There total 9 articles about 1,1-dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-(N-{(R)-α-[N-((S)-1-carboxy-(R)-2-hydroxyprop-1-yl)carbamoyl]-4-hydroxybenzyl}carbamoylmethoxy)-2,3,4,5-tetrahydro-1,2,5-benzothiadiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₅H₆₄N₄O₉S₂

: 501692-40-6
1,1-dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-(N-{(R)-α-[N-((S)-1-carboxy-(R)-2-hydroxyprop-1-yl)carbamoyl]-4-hydroxybenzyl}carbamoylmethoxy)-2,3,4,5-tetrahydro-1,2,5-benzothiadiazepine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 18 - 25 ℃; Inert atmosphere;

Reference yield:

: 501692-60-0
1,1-dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-ethoxycarbonylmethoxy-2,3,4,5-tetrahydro-1,2,5-benzothiadiazepine

: 501692-40-6
1,1-dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-(N-{(R)-α-[N-((S)-1-carboxy-(R)-2-hydroxyprop-1-yl)carbamoyl]-4-hydroxybenzyl}carbamoylmethoxy)-2,3,4,5-tetrahydro-1,2,5-benzothiadiazepine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide / ethanol / 18 - 25 °C / Inert atmosphere

2.1: 2,6-dimethylpyridine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 5 h / 18 - 25 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 4.5 h / 18 - 25 °C / Inert atmosphere

4.1: 4-methyl-morpholine / N,N-dimethyl-formamide / 0.08 h / 18 - 25 °C / Inert atmosphere

4.2: 0.5 h / 18 - 25 °C / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane / 18 - 25 °C / Inert atmosphere

With 4-methyl-morpholine; 2,6-dimethylpyridine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; trifluoroacetic acid; sodium hydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 618908-39-7
C₃₇H₄₉N₃O₇S₂

: 501692-40-6
1,1-dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-(N-{(R)-α-[N-((S)-1-carboxy-(R)-2-hydroxyprop-1-yl)carbamoyl]-4-hydroxybenzyl}carbamoylmethoxy)-2,3,4,5-tetrahydro-1,2,5-benzothiadiazepine

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 4.5 h / 18 - 25 °C / Inert atmosphere

2.1: 4-methyl-morpholine / N,N-dimethyl-formamide / 0.08 h / 18 - 25 °C / Inert atmosphere

2.2: 0.5 h / 18 - 25 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 18 - 25 °C / Inert atmosphere

With 4-methyl-morpholine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;