3-<2-bromo-4-(dimethylamino)phenyl>-7-hydroxy-5-methyl-3H-1,2,3-triazolo<4,5-d>pyrimidine

Base Information

• Chemical Name: 3-<2-bromo-4-(dimethylamino)phenyl>-7-hydroxy-5-methyl-3H-1,2,3-triazolo<4,5-d>pyrimidine
• CAS No.: 220953-44-6
• Molecular Formula: C₁₃H₁₃BrN₆O
• Molecular Weight: 349.19

Synonyms:3-<2-bromo-4-(dimethylamino)phenyl>-7-hydroxy-5-methyl-3H-1,2,3-triazolo<4,5-d>pyrimidine

Chemical Property of 3-<2-bromo-4-(dimethylamino)phenyl>-7-hydroxy-5-methyl-3H-1,2,3-triazolo<4,5-d>pyrimidine

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Technology Process of 3-<2-bromo-4-(dimethylamino)phenyl>-7-hydroxy-5-methyl-3H-1,2,3-triazolo<4,5-d>pyrimidine

There total 4 articles about 3-<2-bromo-4-(dimethylamino)phenyl>-7-hydroxy-5-methyl-3H-1,2,3-triazolo<4,5-d>pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

4-N-<2-bromo-4-(dimethylamino)phenyl>-5-amino-6-hydroxy-2-methylpyrimidin-4-amine (220953-43-5) → 3-<2-bromo-4-(dimethylamino)phenyl>-7-hydroxy-5-methyl-3H-1,2,3-triazolo<4,5-d>pyrimidine (220953-44-6)

Guidance literature:

With acetic acid; sodium nitrite; In dichloromethane; for 4h; Ambient temperature;

DOI:10.1021/jm980224g

Reference yield:

4,6-dichloro-2-methyl-5-nitropyrimidine (13162-43-1) → 3-<2-bromo-4-(dimethylamino)phenyl>-7-hydroxy-5-methyl-3H-1,2,3-triazolo<4,5-d>pyrimidine (220953-44-6)

Guidance literature:

Multi-step reaction with 3 steps

1: dimethylsulfoxide / Ambient temperature

2: 63 percent / Fe, 1N HCl / methanol / Ambient temperature

3: 65 percent / NaNO₂, HOAc / CH₂Cl₂ / 4 h / Ambient temperature

With hydrogenchloride; iron; acetic acid; sodium nitrite; In methanol; dichloromethane; dimethyl sulfoxide;

DOI:10.1021/jm980224g

Reference yield:

3-bromo-N1,N1-dimethylbenzene-1,4-diamine (107100-00-5) → 3-<2-bromo-4-(dimethylamino)phenyl>-7-hydroxy-5-methyl-3H-1,2,3-triazolo<4,5-d>pyrimidine (220953-44-6)

Guidance literature:

Multi-step reaction with 3 steps

1: dimethylsulfoxide / Ambient temperature

2: 63 percent / Fe, 1N HCl / methanol / Ambient temperature

3: 65 percent / NaNO₂, HOAc / CH₂Cl₂ / 4 h / Ambient temperature

With hydrogenchloride; iron; acetic acid; sodium nitrite; In methanol; dichloromethane; dimethyl sulfoxide;

DOI:10.1021/jm980224g

upstream raw materials:

4-N-<2-bromo-4-(dimethylamino)phenyl>-5-amino-6-hydroxy-2-methylpyrimidin-4-amine

4,6-dichloro-2-methyl-5-nitropyrimidine

3-bromo-N₁,N₁-dimethylbenzene-1,4-diamine

Downstream raw materials:

3-<2-bromo-4-(dimethylamino)phenyl>-7-chloro-5-methyl-3H-1,2,3-triazolo<4,5-d>pyrimidine

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