(4aR,8S,8aR)-1-[(1R)-2-hydroxy-1-phenylethyl]-8-methyldecahydroquinoline

Base Information

Chemical Name:(4aR,8S,8aR)-1-[(1R)-2-hydroxy-1-phenylethyl]-8-methyldecahydroquinoline
CAS No.:1559757-30-0
Molecular Formula:C₁₈H₂₇NO
Molecular Weight:273.418
Hs Code.:

Synonyms:(4aR,8S,8aR)-1-[(1R)-2-hydroxy-1-phenylethyl]-8-methyldecahydroquinoline

Suppliers and Price of (4aR,8S,8aR)-1-[(1R)-2-hydroxy-1-phenylethyl]-8-methyldecahydroquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4aR,8S,8aR)-1-[(1R)-2-hydroxy-1-phenylethyl]-8-methyldecahydroquinoline

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Technology Process of (4aR,8S,8aR)-1-[(1R)-2-hydroxy-1-phenylethyl]-8-methyldecahydroquinoline

There total 2 articles about (4aR,8S,8aR)-1-[(1R)-2-hydroxy-1-phenylethyl]-8-methyldecahydroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1559756-91-0
(3R,7aR,11S,11aS)-11-methyl-5-oxo-3-phenyldecahydrooxazolo[2,3-j]quinoline

: 1559757-30-0
(4aR,8S,8aR)-1-[(1R)-2-hydroxy-1-phenylethyl]-8-methyldecahydroquinoline

Guidance literature:: With aluminum (III) chloride; lithium aluminium tetrahydride; In tetrahydrofuran; at -78 - 20 ℃; for 3.5h; stereoselective reaction;
DOI:10.1002/chem.201302894

Reference yield:

: 56613-80-0
D-2-phenylglycinol

: 1559757-30-0
(4aR,8S,8aR)-1-[(1R)-2-hydroxy-1-phenylethyl]-8-methyldecahydroquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: magnesium sulfate / toluene / 24 h / Reflux

2: lithium aluminium tetrahydride; aluminum (III) chloride / tetrahydrofuran / 3.5 h / -78 - 20 °C

With aluminum (III) chloride; lithium aluminium tetrahydride; magnesium sulfate; In tetrahydrofuran; toluene;
DOI:10.1002/chem.201302894