(1R,2S)-2-[4-(tert-Butyl-diphenyl-silanyloxy)-2,2-dimethyl-1-methylene-butyl]-5-oxo-cyclopentanecarboxylic acid ethyl ester

Base Information

Chemical Name:(1R,2S)-2-[4-(tert-Butyl-diphenyl-silanyloxy)-2,2-dimethyl-1-methylene-butyl]-5-oxo-cyclopentanecarboxylic acid ethyl ester
CAS No.:187869-76-7
Molecular Formula:C₃₁H₄₂O₄Si
Molecular Weight:506.758
Hs Code.:

Synonyms:(1R,2S)-2-[4-(tert-Butyl-diphenyl-silanyloxy)-2,2-dimethyl-1-methylene-butyl]-5-oxo-cyclopentanecarboxylic acid ethyl ester

Suppliers and Price of (1R,2S)-2-[4-(tert-Butyl-diphenyl-silanyloxy)-2,2-dimethyl-1-methylene-butyl]-5-oxo-cyclopentanecarboxylic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R,2S)-2-[4-(tert-Butyl-diphenyl-silanyloxy)-2,2-dimethyl-1-methylene-butyl]-5-oxo-cyclopentanecarboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R,2S)-2-[4-(tert-Butyl-diphenyl-silanyloxy)-2,2-dimethyl-1-methylene-butyl]-5-oxo-cyclopentanecarboxylic acid ethyl ester

There total 5 articles about (1R,2S)-2-[4-(tert-Butyl-diphenyl-silanyloxy)-2,2-dimethyl-1-methylene-butyl]-5-oxo-cyclopentanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 139897-19-1
(2-bromoethoxy)(tert-butyl)diphenylsilane

: 187869-76-7
(1R,2S)-2-[4-(tert-Butyl-diphenyl-silanyloxy)-2,2-dimethyl-1-methylene-butyl]-5-oxo-cyclopentanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / (i-Pr)2NH, BuLi / hexane; tetrahydrofuran / 96 h / Ambient temperature

2: 75 percent / piperidine, BuLi / hexane; diethyl ether / 12 h / Ambient temperature

3: 63 percent / BuLi / hexane; diethyl ether / 3 h / 0 °C

4: 68 percent / B-bromo-9-borabicyclo<3.3.1>nonane / CH₂Cl₂ / 2.5 h / 0 °C

5: 70 percent / BuLi, MgBr*Et₂O, CuBr*MeS₂ / pentane; tetrahydrofuran / 3 h / -78 °C

6: 85 percent / ethanol / 115 h / Heating

With piperidine; n-butyllithium; copper(I) bromide dimethylsulfide complex; 9-bromo-9-bora-bicyclo[3.3.1]nonane; diisopropylamine; magnesium bromide; In tetrahydrofuran; diethyl ether; ethanol; hexane; dichloromethane; pentane;
DOI:10.1002/hlca.19970800114

Reference yield:

: 187869-66-5
tert-Butyl-(3,3-dimethyl-pent-4-ynyloxy)-diphenyl-silane

: 187869-76-7
(1R,2S)-2-[4-(tert-Butyl-diphenyl-silanyloxy)-2,2-dimethyl-1-methylene-butyl]-5-oxo-cyclopentanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 68 percent / B-bromo-9-borabicyclo<3.3.1>nonane / CH₂Cl₂ / 2.5 h / 0 °C

2: 70 percent / BuLi, MgBr*Et₂O, CuBr*MeS₂ / pentane; tetrahydrofuran / 3 h / -78 °C

3: 85 percent / ethanol / 115 h / Heating

With n-butyllithium; copper(I) bromide dimethylsulfide complex; 9-bromo-9-bora-bicyclo[3.3.1]nonane; magnesium bromide; In tetrahydrofuran; ethanol; dichloromethane; pentane;
DOI:10.1002/hlca.19970800114

Reference yield:

: 187869-61-0
4-(tert-butyldiphenysilanyloxy)-2,2-dimethylbutyraldehyde

: 187869-76-7
(1R,2S)-2-[4-(tert-Butyl-diphenyl-silanyloxy)-2,2-dimethyl-1-methylene-butyl]-5-oxo-cyclopentanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 75 percent / piperidine, BuLi / hexane; diethyl ether / 12 h / Ambient temperature

2: 63 percent / BuLi / hexane; diethyl ether / 3 h / 0 °C

3: 68 percent / B-bromo-9-borabicyclo<3.3.1>nonane / CH₂Cl₂ / 2.5 h / 0 °C

4: 70 percent / BuLi, MgBr*Et₂O, CuBr*MeS₂ / pentane; tetrahydrofuran / 3 h / -78 °C

5: 85 percent / ethanol / 115 h / Heating

With piperidine; n-butyllithium; copper(I) bromide dimethylsulfide complex; 9-bromo-9-bora-bicyclo[3.3.1]nonane; magnesium bromide; In tetrahydrofuran; diethyl ether; ethanol; hexane; dichloromethane; pentane;
DOI:10.1002/hlca.19970800114