1-(2,4-dimethylphenyl)-4-(4-methylbenzenesulfonyl)-5-(trifluoromethyl)-1H-imidazole

Base Information

Chemical Name:1-(2,4-dimethylphenyl)-4-(4-methylbenzenesulfonyl)-5-(trifluoromethyl)-1H-imidazole
CAS No.:1613146-17-0
Molecular Formula:C₁₉H₁₇F₃N₂O₂S
Molecular Weight:394.417
Hs Code.:

Synonyms:1-(2,4-dimethylphenyl)-4-(4-methylbenzenesulfonyl)-5-(trifluoromethyl)-1H-imidazole

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Chemical Property of 1-(2,4-dimethylphenyl)-4-(4-methylbenzenesulfonyl)-5-(trifluoromethyl)-1H-imidazole

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Technology Process of 1-(2,4-dimethylphenyl)-4-(4-methylbenzenesulfonyl)-5-(trifluoromethyl)-1H-imidazole

There total 3 articles about 1-(2,4-dimethylphenyl)-4-(4-methylbenzenesulfonyl)-5-(trifluoromethyl)-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 38622-91-2,36635-61-7
[(p-methylphenyl)sulfonylmethyl]isonitrile

: 70314-82-8
N-(2,4-dimethylphenyl)-2,2,2-trifluoroethanimidoyl chloride

: 1613146-17-0
1-(2,4-dimethylphenyl)-4-(4-methylbenzenesulfonyl)-5-(trifluoromethyl)-1H-imidazole

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 20 ℃; for 2.25h; Inert atmosphere;
DOI:10.1016/j.jfluchem.2014.04.013

Reference yield:

: 38622-91-2,36635-61-7
[(p-methylphenyl)sulfonylmethyl]isonitrile

: C₁₆H₁₃F₃N₄

: 1613146-17-0
1-(2,4-dimethylphenyl)-4-(4-methylbenzenesulfonyl)-5-(trifluoromethyl)-1H-imidazole

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1134/S1070428019040122

Reference yield:

: 70314-82-8
N-(2,4-dimethylphenyl)-2,2,2-trifluoroethanimidoyl chloride

: 1613146-17-0
1-(2,4-dimethylphenyl)-4-(4-methylbenzenesulfonyl)-5-(trifluoromethyl)-1H-imidazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0.25 h / 20 °C

1.2: 1.5 h / 20 °C

2.1: sodium hydride / tetrahydrofuran / 1 h / 20 °C

With sodium hydride; In tetrahydrofuran;
DOI:10.1134/S1070428019040122